Results 251 to 260 of about 6,604,045 (304)

Multienzyme assembly of a p53 transcription complex

Nature Structural & Molecular Biology, 2007
Proline isomerization of the p53 transactivation domain has a central role in coordinating kinase signaling pathways that assemble the core p53 transcription complex.
Ted R. Hupp, Malcolm D. Walkinshaw
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A Nanopore Sensing Assay Resolves Cascade Reactions in a Multienzyme System.

Angewandte Chemie, 2022
Enzymatic cascade reactions are widely used to synthesize complex molecules from simple precursors. The major underlying mechanism of cascade reactions is substrate channeling, where intermediates of different enzymatic steps are not in equilibrium with ...
Yingying Sheng, Ke Zhou, Lei Liu, Hai‐Chen Wu   +3 more
semanticscholar   +1 more source

Tryptophan synthase: A multienzyme complex with an intramolecular tunnel

The Chemical Record, 2001
AbstractTryptophan synthase is a classic enzyme that channels a metabolic intermediate, indole. The crystal structure of the tryptophan synthase α2β2 complex from Salmonella typhimurium revealed for the first time the architecture of a multienzyme complex and the presence of an intramolecular tunnel. This remarkable hydrophobic tunnel provides a likely
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The role of multienzyme complexes in integration of cellular metabolism

Journal of Theoretical Biology, 1986
The notion of the "primary block" of cellular metabolism designated as "metabolic system" is introduced. Metabolic system is defined as a metabolic pathway which corresponds to the structurally ordered multienzyme complex. The complex of glycolytic enzymes which catalyzes the anaerobic reduction of glucose-6-phosphate with production of ATP may serve ...
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Preparation of high-quality resistant dextrin through pyrodextrin by a multienzyme complex

Food Bioscience, 2022
Zhanzhi Liu, J. Liu, Liqiong Ren, Jing Wu, Sheng Chen   +4 more
semanticscholar   +1 more source

Theoretical study of the catalytic mechanism of E1 subunit of pyruvate dehydrogenase multienzyme complex from Bacillus stearothermophilus.

Biochemistry, 2013
Pyruvate dehydrogenase multienzyme complex (PDHc) is a member of a family of 2-oxo acid dehydrogenase (OADH) multienzyme complexes involved in several central points of oxidative metabolism, and the E1 subunit is the most important component in the ...
X. Sheng, Yongjun Liu
semanticscholar   +1 more source

A Multienzyme Complex for De Novo Purine Biosynthesis

1977
Multienzyme complexes are defined as aggregates of different functionally related enzymes integrated into highly organized structures by non-covalent bonds. Such a structural arrangement is considered to confer a catalytic advantage in that an unstable intermediate may be transferred more efficiently from one active site to the next.
Dorit Sauer, E McCairns, Gemma Madsen, Peter B. Rowe   +3 more
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Data-Driven Evolutionary Design of Multienzyme-like Nanozymes.

Journal of the American Chemical Society
Multienzyme-like nanozymes are nanomaterials with multiple enzyme-like activities and are the focus of nanozyme research owing to their ability to facilitate cascaded reactions, leverage synergistic effects, and exhibit environmentally responsive ...
Yujie Jiang, Zibei Chen, Ning Sui, Zhiling Zhu   +3 more
semanticscholar   +1 more source

A possible origin of RNA catalysis in multienzyme complexes

Origins of life and evolution of the biosphere, 1989
Numerous attempts have recently been made to ascribe a preeminent role to RNA enzymes in primitive life systems. A model is proposed in which coenzyme-dependent RNA enzymes were initially organized in multienzyme complexes featuring (1) the continuous attachment of substrates to CoA-like carriers, as in fatty acid synthesis; and (2) the ordering of RNA
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The 2-oxoacid dehydrogenase multienzyme complex of Haloferax volcanii

Extremophiles, 2007
Those aerobic archaea whose genomes have been sequenced possess four adjacent genes that, by sequence comparisons with bacteria and eukarya, appear to encode the component enzymes of a 2-oxoacid dehydrogenase multienzyme complex. However, no catalytic activity of any such complex has ever been detected in the archaea.
Michael J. Danson, D. M. Al-Mailem, David W. Hough   +2 more
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