Results 61 to 70 of about 6,604,045 (304)

Novel binding motif and new flexibility revealed by structural analyses of a pyruvate dehydrogenase-dihydrolipoyl acetyltransferase subcomplex from the Escherichia coli pyruvate dehydrogenase multienzyme complex. [PDF]

J Biol Chem, 2014
Background: The E. coli pyruvate dehydrogenase complex containing E1p, E2p, and E3 components converts pyruvate to acetyl-CoA. Results: The E1p-E2p subcomplex revealed a novel binding motif relative to the only other known example.
Arjunan P, Wang J, Nemeria NS, Reynolds S, Brown I, Chandrasekhar K, Calero G, Jordan F, Furey W.   +8 more
europepmc   +2 more sources

The Urea Carboxylase and Allophanate Hydrolase Activities of Urea Amidolyase Are Functionally Independent [PDF]

, 2016
Urea amidolyase (UAL) is a multifunctional biotin-dependent enzyme that contributes to both bacterial and fungal pathogenicity by catalyzing the ATP-dependent cleavage of urea into ammonia and CO2.
Bahler, Baker, Balotra, Bratlie, Chapman-Smith, Chen, Chen, Cheng, Dumetz, Fan, Fan, Geck, Ghosh, Greenberg, Hettwer, Huang, Ianeselli, James, Kaessmann, Kanamori, Kanamori, Khosla, Kimura, Koonin, Kotlyar, Kozer, Kulkarni, Kulkarni, Kuriyan, Lawrence, Lherbet, Lietzan, Lin, Lorenz, Marsh, Moxley, Navarathna, Navarathna, Ribeiro, Shapir, Shapir, Singh, Spivey, Strope, Thanabalu, Thoden, Thompson, Whitney, Zeczycki   +48 more
core   +2 more sources

The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy

Frontiers in Nutrition, 2021
Anaerobic glycolysis is the process by which glucose is broken down into pyruvate and lactate and is the primary metabolic pathway in sepsis. The pyruvate dehydrogenase complex (PDHC) is a multienzyme complex that serves as a critical hub in energy ...
Zhenhua Zeng, Qiaobing Huang, Liangfeng Mao, Jie Wu, Sheng An, Zhongqing Chen, Weijin Zhang   +6 more
doaj   +1 more source

Design of a New Multienzyme Complex Synthesis System Based on Yarrowia lipolytica Simultaneously Secreted and Surface Displayed Fusion Proteins for Sustainable Production of Fatty Acid-Derived Hydrocarbons

ACS Sustainable Chemistry and Engineering, 2018
In order to address the challenges of relative ratio and relative position among individual enzymes and substrate channeling in multienzyme biocatalysis, we propose a new one-pot genetically encoded self-assembly system as an alternative to the heavy ...
Kaixin Yang, Fei Li, Yangge Qiao, Qinghua Zhou, Zhiming Hu, Yaojia He, Yunjun Yan, Li Xu, C. Madzak, Jinyong Yan   +9 more
semanticscholar   +1 more source

Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]

, 2015
O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi, Kenyond, Nicholas J, Li, Yanhong, Louie, Angelique Y, Muthana, Musleh M, Santra, Abhishek, Tasnima, Nova, Yu, Hai, Zeng, Jie   +8 more
core   +1 more source

Alternative Copper-Based Single-Atom Nanozyme with Superior Multienzyme Activities and NIR-II Responsiveness to Fight against Deep Tissue Infections

Research, 2023
Nanozymes are considered to represent a new era of antibacterial agents, while their antibacterial efficiency is limited by the increasing tissue depth of infection.
Jiaxiang Bai, Yonghai Feng, Wenming Li, Zerui Cheng, J. Rosenholm, Huiling Yang, G. Pan, Hongbo Zhang, D. Geng   +8 more
semanticscholar   +1 more source

Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. [PDF]

J Biol Chem, 2012
Background: Conotoxins can be utilized to investigate enzyme-assisted folding of disulfide-rich peptides. Results: Various ER-resident cone snail enzymes act in concert to accelerate the oxidative folding of conotoxins and modulate their conformation by ...
Safavi-Hemami H, Gorasia DG, Steiner AM, Williamson NA, Karas JA, Gajewiak J, Olivera BM, Bulaj G, Purcell AW.   +8 more
europepmc   +2 more sources

A Rado theorem for complex spaces [PDF]

arXiv, 2021
We generalize Rado's extension theorem to complex spaces.
arxiv  

Self-Organization and Information Processing: from Basic Enzymatic Activities to Complex Adaptive Cellular Behavior [PDF]

, 2021
One of the main aims of current biology is to understand the origin of the molecular organization that underlies the complex dynamic architecture of cellular life.
Carrasco Pujante, José, Fedetz, María, López Fernández de Villaverde, José Ignacio, Malaina Celada, Iker, Martínez de la Fuente Martínez, Ildefonso Abel, Martínez Fernández, Luis   +5 more
core   +1 more source

Block copolymer-quantum dot micelles for multienzyme colocalization [PDF]

, 2012
To mimic the structure and functionality of multienzyme complexes, which are widely present in Nature, Pluronic-based micelles were designed to colocalize multiple enzymes.
Jia, Feng, Mallapragada, Surya, Mallapragada, Surya, Narasimhan, Balaji, Narasimhan, Balaji, Zhang, Yanjie   +5 more
core   +3 more sources