Results 151 to 160 of about 17,949 (246)

The Genetic Landscape of Diabetes Mellitus: Lessons from Monogenic and Polygenic Forms. [PDF]

Life (Basel)
Nilo D, Nilo R, Sircana MC, Sasso FC, Acierno C, Bonfrate L, Caturano A.   +6 more
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

<i>TLR7</i> mutations leading to enhanced TLR7 signaling in humans. [PDF]

J Hum Immun
Crow YJ, Gantier MP.
europepmc   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, Volume 59, Issue 7, July 2026.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

Genetic and Environmental Determinants of Spontaneous Preterm Birth: Focus on Progesterone Receptor Gene Variants. [PDF]

Int J Mol Sci
Kadivnik M, Kralik K, Šijanović S, Wagner J.   +3 more
europepmc   +1 more source

Use of the Multidimensional Haemophilia Pain Questionnaire (MHPQ) in Patients With Severe Haemophilia A Treated With Emicizumab: A Pilot Cross‐Sectional, Single‐Centre Study

Haemophilia, Volume 32, Issue 4, Page 1060-1066, July/August 2026.
ABSTRACT Background Despite effective bleed prevention with Emicizumab, pain remains a relevant clinical burden in adults with severe haemophilia A (sHA). A multidimensional assessment is needed to better characterize contemporary haemophilia‐related pain.
Ilenia Lorenza Calcaterra, Sofia Donnarumma, Guido D'Errico, Carmine De Luca, Chiara Caputo, Paola Ciciola, Ernesto Cimino, Matteo Di Minno   +7 more
wiley   +1 more source

Unraveling the Genetic and Molecular Architecture of Autism Spectrum Disorder: Implications for Clinical Genetics and Genomic Diagnostics. [PDF]

Int J Mol Sci
Treccarichi S, Vinci M, Virgillito M, Musumeci A, Bruno F, Papa C, Galati Rando R, Marano P, Greco D, Fallea A, Brancato D, Calì S, Garcia G, Federico C, Saccone S, Calì F.   +15 more
europepmc   +1 more source

Perioperative Outcomes in Factor XI Deficiency: A Systematic Review

Haemophilia, Volume 32, Issue 4, Page 886-896, July/August 2026.
ABSTRACT Background Congenital factor XI (FXI) deficiency has a variable bleeding phenotype, and FXI activity alone does not predict perioperative bleeding. Management practices remain heterogeneous, and available evidence derives from case reports, small case series, and retrospective cohorts.
Zainab Al‐Housni, Raeesah Mohammed, Silvio Ligia, Jim Douketis, Chatree Chai‐Adisaksopha, Alfonso Iorio, Davide Matino   +6 more
wiley   +1 more source

The role of γ-secretase in familial hidradenitis suppurativa: Implications for pathogenesis and targeted therapy. [PDF]

JAAD Case Rep
Desta B, Korytnikova E, Tessier-Kay M, Klufas T, Lu J, Sarfo A, Zhou AE.   +6 more
europepmc   +1 more source

Genetic Evaluation and Pregnancy Outcomes in Foetuses With Overgrowth at a Tertiary Referral Center

Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.
ABSTRACT Fetal overgrowth is defined as one or more biometric parameters exceeding the 90th–97th percentile or 2 standard deviations above the mean for gestational age. This study aimed to evaluate genetic findings in foetuses diagnosed with sonographic overgrowth.
Xiaoqing Wu, Qingmei Shen, Xiaorui Xie, Yuqin Chen, Bin Liang, Meiying Wang, Danhua Guo, Na Lin, Liangpu Xu   +8 more
wiley   +1 more source