Results 31 to 40 of about 33,124 (264)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Homochiral Multifunctional Metal-Organic Framework with Rod-Shaped Secondary Building Units

Nanomaterials, 2017
A new homochiral multifunctional metal-organic framework, [Zn2(CTBA)2·H2O] (JUC-112), was synthesized under solvothermal conditions, through the design of chiral ligand 4-(3-carboxy-2,2,3-trimethylcyclopentanecarboxamido) benzoic acid (H2CTBA) based on ...
Kun Cai, Nian Zhao, Ning Zhang, Fu-Xing Sun, Qing Zhao, Guang-Shan Zhu   +5 more
doaj   +1 more source

Foldable-circuit-enabled miniaturized multifunctional sensor for smart digital dust

Chip, 2022
Smart dust, which refers to miniaturized, multifunctional sensor motes, would open up data acquisition opportunities for Internet of Things (IoT) and Environmental protection applications. However, critical obstacles remain challenging in the integration
Chun-Yu You, Bo-Fan Hu, Bo-Rui Xu, Zi-Yu Zhang, Bin-Min Wu, Gao-Shan Huang, En-Ming Song, Yong-Feng Mei   +7 more
doaj   +1 more source

The potential of DNA origami to build multifunctional materials

Multifunctional Materials, 2020
AbstractThe development of the DNA origami technique has revolutionized the field of DNA nanotechnology as it allows to create virtually any arbitrarily shaped nanostructure out of DNA on a 10–100 nm length scale by a rather robust self-assembly process.
Kosti Tapio, Ilko Bald
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Highly Aligned Graphene Aerogels for Multifunctional Composites

Nano-Micro Letters
Highlights Aligned graphene building blocks take full advantages of the outstanding properties of graphene. Comprehensive review of recent advancements in the utilization of highly aligned graphene aerogels for multifunctional applications.
Ying Wu, Chao An, Yaru Guo, Yangyang Zong, Naisheng Jiang, Qingbin Zheng, Zhong-Zhen Yu   +6 more
doaj   +1 more source

The use of information technologies and communication assistive technology as applied in the construction of knowledge of students with visual disabilities who attend rooms multifunction resources

Revista Ibero-Americana de Estudos em Educação, 2016
This research aimed to investigate the contribution brought by the use of information and communication technologies applied to assistive technology in the construction of knowledge of students with visual impairment who attended the multifunction ...
Raquel Rosan Christino Gitahy, Jessé Pessoa da Silva, Adriana Aparecida de Lima Terçariol   +2 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source