Results 91 to 100 of about 1,913,001 (298)

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Domain Insertion Effectively Regulates the Mechanical Unfolding Hierarchy of Elastomeric Proteins: Toward Engineering Multifunctional Elastomeric Proteins

, 2016
The architecture of elastomeric proteins controls fine-tuned nanomechanical properties of this class of proteins. Most elastomeric proteins are tandem modular in structure, consisting of many individually folded domains of varying stability.
Hongbin Li (339287), Qing Peng (148438)
core   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Utilizing small molecules to probe and harness the proteome by pooled protein tagging with ligandable domains

Frontiers in Pharmacology
Multifunctional ligand-binding domains have revolutionized cell biology by enabling the precise visualization and manipulation of fused proteins of interest through small molecule probes.
Katherine E. Larrimore, Yevgeniy V. Serebrenik   +1 more
doaj   +1 more source

Kingella kingae PilC1 and PilC2 are adhesive multifunctional proteins that promote bacterial adherence, twitching motility, DNA transformation, and pilus biogenesis. [PDF]

PLoS Pathog, 2022
Sacharok AL, Porsch EA, Yount TA, Keenan O, St Geme JW.   +4 more
europepmc   +1 more source

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Preface (Bacterial NanoCellulose: A Sophisticated Multifunctional Material)

, 2016
Bacterial NanoCellulose: A Sophisticated Multifunctional ...
Gama, Francisco Miguel,, Gatenholm, Paul,, Klemm, Dieter,   +2 more
core  

An investigation of the feasibility of a spacecraft multifunctional structure using commercial electrochemical cells

, 2009
Multifunctional structures offer the potential for large savings in the mass and cost of spacecraft missions. By combining the functions of one or more subsystems with the primary structure, mass is reduced and internal volume freed up for additional ...
Roberts, Samuel Charles
core   +1 more source

Cold shock proteins: from cellular mechanisms to pathophysiology and disease

Cell Communication and Signaling, 2018
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the presence of one or more cold shock domains. In humans, the best characterized members of this family are denoted Y-box binding proteins, such as Y-box binding protein ...
Jonathan A. Lindquist, Peter R. Mertens
doaj   +1 more source