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ALR, the multifunctional protein
Orvosi Hetilap, 2015ALR is a mystic protein. It has a so called “long” 22 kDa and a “short” 15 kDa forms. It has been described after partial hepatectomy and it has just been considered as a key protein of liver regeneration. At the beginning of the 21st century it has been revealed that the “long” form is localized in the mitochondrial intermembrane space and it is an ...
Tibor, Balogh, András, Szarka
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The Multifunctional Protein C System
Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2005The protein C pathway is a major regulator of blood coagulation, since it controls the conversion of prothrombin to thrombin through a feedback inhibition mechanism. Protein C circulates in plasma as an inactive zymogen and is activated on the surface of endothelial cells by the thrombin-thrombomodulin complex, a process that can be further enhanced ...
F, Espana +5 more
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Endophilin-1: a multifunctional protein
The International Journal of Biochemistry & Cell Biology, 2002Endophilin-1, a cytoplasmic Src homology 3 (SH3) domain-containing protein, localises in brain presynaptic nerve termini. Endophilin dimerises through its N-terminus, and participates at multiple stages in clathrin-coated endocytosis, from early membrane invagination to synaptic vesicle uncoating.
Anne T, Reutens, C Glenn, Begley
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Dystroglycan: a multifunctional adaptor protein
Biochemical Society Transactions, 2005Dystroglycan, a ubiquitous membrane-spanning cell adhesion molecule, is a crucial link between the actin cytoskeleton and the extracellular matrix. With a wide expression pattern and multiple interacting proteins, not only is dystroglycan now thought to be important as a structural molecule but also new research has suggested that it has a role in cell
J R, Higginson, S J, Winder
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Insect transferrins: Multifunctional proteins
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012Many studies have been done evaluating transferrin in insects. Genomic analyses indicate that insects could have more than one transferrin. However, the most commonly studied insect transferrin, Tsf1, shows greatest homology to mammalian blood transferrin.Aspects of insect transferrin structure compared to mammalian transferrin and the roles ...
Dawn L, Geiser, Joy J, Winzerling
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MIM: a multifunctional scaffold protein
Journal of Molecular Medicine, 2007The protein "missing in metastasis", known as MIM, has been characterised as an actin-binding scaffold protein that may be involved in cancer metastasis. In this paper, we summarise the literature surrounding the role of MIM in actin and membrane dynamics and in signalling to transcription via the sonic hedgehog pathway.
Laura M, Machesky, Simon A, Johnston
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The Insulin Receptor: A Multifunctional Protein
Diabetes, 1990The insulin receptor is a multifunctional protein encoded by a modular gene. Certain discrete domains within the insulin-receptor structure subserve specific functional properties. In some instances, these discrete domains are encoded by individual exons.
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Follistatin: A Multifunctional Regulatory Protein
Frontiers in Neuroendocrinology, 1998Follistatin was first described in 1987 as a follicle-stimulating hormone inhibiting substance present in ovarian follicular fluid. We now know that this effect of follistatin is only one of its many properties in a number of reproductive and nonreproductive systems.
D J, Phillips, D M, de Kretser
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[Lactoferrin: a multifunctional protein].
Medecine sciences : M/S, 2009Lactoferrin (Lf) is an iron-binding glycoprotein of the transferrin family that is expressed and secreted by glandular cells and found in the secondary granules of neutrophils from which it is released in infected tissues and blood during the inflammatory process. Initially described as an iron-binding molecule with bacteriostatic properties, Lf is now
Pierce, Annick +2 more
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CCN Proteins: Multifunctional Signalling Regulators
Lancet, The, 2004Although little is known as yet about the processes that coordinate cell-signalling pathways, matrix proteins are probably major players in this type of global control. The CCN (cyr61, ctgf, nov) proteins are an important family of matricellular regulatory factors involved in internal and external cell signalling.
Bernard V. Perbal
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