Results 121 to 130 of about 618 (211)

Redox‐responsive dual‐drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance

open access: yesSmart Molecules, EarlyView.
This study presents a novel glutathione‐activatable prodrug nanomedicine (cRGD‐PEG‐PGlu‐NP (ssTrypsin & CDDP)) that co‐encapsulates cisplatin and a masked protease to combat cisplatin resistance. The dual‐drug system selectively targets resistant tumor cells, enhancing the efficacy of cisplatin while minimizing systemic toxicity.
Xiaolan Yin   +10 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

Revealing the interplay between decarbonisation, circularity, and cost-effectiveness in building energy renovation. [PDF]

open access: yesNat Commun
Zhang C   +9 more
europepmc   +1 more source

Advancements and Challenges in Second‐ and Third‐Generation Biofuels: A Comparative Analysis of Lignocellulosic and Algal Feedstocks

open access: yesSafety Science and Technology, EarlyView.
ABSTRACT Advanced biofuels derived from nonfood biomass are increasingly recognized as strategic components of low‐carbon energy systems, particularly for sectors where direct electrification remains difficult. Second‐generation biofuels from lignocellulosic residues and third‐generation biofuels from algal and aquatic biomass offer complementary ...
Majid Saidi, Amirreza Ahmadbozorgi
wiley   +1 more source

Concrete in architecture: Redefining form, space, function, and insights from bibliometric analysis

open access: yesStructural Concrete, EarlyView.
Abstract Concrete has become a cornerstone in architectural and engineering innovation, as it seamlessly integrates structural performance with artistic expression. Its evolution from ancient opus caementicium to contemporary ultra‐high‐performance concrete illustrates its adaptability to the change in technological, environmental, and design paradigms.
Mouhcine Benaicha   +2 more
wiley   +1 more source

Printing to Fight Antimicrobial Resistance Through Nano/Microstructured Platforms

open access: yesThe Chemical Record, EarlyView.
Additive manufacturing enables the rational design of structured antimicrobial platforms across multiple length scales, from nanofibrous scaffolds and droplet microreactors to 3D and 4D printed constructs. By engineering confinement, interfacial chemistry, and stimuli‐responsive release, these systems exert localized action through complementary ...
Giorgia Puleo   +11 more
wiley   +1 more source

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