Results 41 to 50 of about 23,774 (296)

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Influence of multimodal anesthesia and analgesia on mechanisms of blood circulation adaptation of oncogynecologic patients in the postoperative period

Медицинский вестник Юга России, 2018
Objective: to assess the influence and eff ectiveness of multimodal anesthesia and analgesia from the standpoint of personalization of compensatory mechanisms of blood circulation adaptation in oncogynecologic patients in the postoperative period ...
S. V. Tumanyan, T. I. Moiseyenko, O. V. Oros, S. A. Chekmezova, A. V. Shepelenko   +4 more
doaj   +1 more source

Short‐Term Outcomes of Robot‐Assisted Versus Laparoscopic Colectomy for Colon Cancer: A Propensity Score‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
This study compared short‐term outcomes of robot‐assisted versus laparoscopic colectomy for colon cancer using 1:1 propensity score matching. Among 218 matched pairs, robot‐assisted colectomy was associated with reduced blood loss, fewer conversions to open surgery, lower overall complication rates, and shorter hospital stays, despite longer operative ...
Akira Inoue, Yujiro Nishizawa, Yoshinori Kagawa, Masahiro Hashimoto, Shinya Kato, Yoshihiro Morimoto, Taishi Hata, Makoto Fujii, Masaaki Motoori, Kazumasa Fujitani   +9 more
wiley   +1 more source

Development of a Multimodal Analgesia Protocol for Perioperative Acute Pain Management for Lower Limb Amputation

Pain Research and Management, 2018
Multimodal analgesia may include pharmacological components such as regional anesthesia, opioid and nonopioid systemic analgesics, nonsteroidal anti-inflammatories, and a variety of adjuvant agents. Multimodal analgesia has been reported for a variety of
Roberta De Jong, Alexander J. Shysh
doaj   +1 more source

Short‐Term Outcomes and Cost Drivers of Emergency Surgery for Acute Abdominal Disease in Super‐Elderly Patients: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study analyzed patients aged ≥ 85 years undergoing emergency abdominal surgery, focusing on short‐term outcomes and inpatient cost structure under the Japanese DPC system. Although major complications occurred in 19.4% of patients, more than 70% were discharged home.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shojiro Hata, Hirokazu Yamaguchi   +8 more
wiley   +1 more source

Liposome bupivacaine (EXPAREL®) for extended pain relief in patients undergoing ileostomy reversal at a single institution with a fast-track discharge protocol: an IMPROVE Phase IV health economics trial

Journal of Pain Research, 2013
Jon D VogelDepartment of Colorectal Surgery, Cleveland Clinic, Digestive Disease Institute, Department of Colorectal Surgery, Cleveland, OH, USABackground: Postoperative opioid use following ileostomy reversal procedures contributes to postoperative ...
Vogel JD
doaj  

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

Eficiencia de la analgesia multimodal en el manejo del dolor postoperatorio en pacientes sometidos a cirugías ortopédicas electivas en el HEODRA marzo - agosto 2019

, 2020
Tesis (Dr. Especialista en Anestesiología)-Universidad Nacional Autónoma de Nicaragua, LeónEn los últimos años, han aparecido distintos conceptos innovadores, para el tratamiento del dolor postoperatorio.
Bermúdez Munguía, Karen Patricia
core  

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Extended pain relief trial utilizing infiltration of Exparel®, a long-acting multivesicular liposome formulation of bupivacaine: a Phase IV health economic trial in adult patients undergoing open colectomy

Journal of Pain Research, 2012
Stephen M CohenAtlanta Colon and Rectal Surgery, PA, Atlanta, GA, USABackground: The majority of surgical patients experience significant levels of pain after a procedure.
Cohen SM
doaj