Results 61 to 70 of about 11,210,584 (306)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Metaphor in the ESP engineering context [PDF]

Ibérica, 2013
The explicit use of metaphor in the EFL classroom has been documented to enhance the communicative skills of learners (Cameron & Low, 1999; Cortazzi & Jin, 1999; Low, 1999; Littlemore & Low, 2006).
Ana Roldán Riejos, Paloma Ubeda Mansilla   +1 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

AquaVib: Enabling the Separate Evaluation of Effects Induced by Acoustic Pressure and Particle Motion on Aquatic Organisms

Journal of Marine Science and Engineering
Scientific awareness is rising regarding fish and sea invertebrates’ sensitivity to the sound field’s particle motion component. The AquaVib, a distinctive laboratory setup, provides a practical methodology for controlled sound exposure experiments on ...
Pablo Pla, Christ A. F. de Jong, Mike van der Schaar, Marta Solé, Michel André   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Ecological Approach to Multimodal System Design [PDF]

, 1999
Following the ecological approach to visual perception, this paper presents a framework that emphasizes the role of vision on referring actions. In particular, affordances are utilized to explain gestures variability in a multimodal human-computer interaction.
de Angeli, Antonella, Wolff, Frédéric, Romary, Laurent, Gerbino, Walter   +3 more
openaire   +3 more sources

A multimodal social semiotic analysis of a museum rock art display [PDF]

, 2009
Readers must seek for permission to reproduce this workThis paper will report on research on different design aspects of museum displays in a permanent and a mobile museum context.
Rall, Medeé
core   +2 more sources

Acupuncture for cognitive functions in post-COVID-19 condition: study protocol of a three-armed, randomized controlled trial with multimodal MRI

Frontiers in Medicine
BackgroundPost-COVID-19 condition (PCC), commonly called long COVID, is a prevalent sequela of SARS-CoV-2 infection and can affect multiple organ systems. Cognitive dysfunction is one of the most common symptoms in PCC, with a prevalence of 22%.
Tingting Luo, Tingting Luo, Yang Luo, Dafeng Liu, Hongjiao Jin, Yi An, Jinwei Huang, Kun Luo, Yan Guo, Dan Wang, Liang Huang, Xi Wu   +11 more
doaj   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source