Results 31 to 40 of about 10,962 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Optimal consolidation center to improve urban freight transport: a case of student accommodation in a higher education institution

Multimodal Transportation, 2022
Cities across the world are expanding as a result of urbanization, resulting in growing demand for goods and services, mainly through online sales. This has resulted in the need for an urban consolidation center (UCC) to minimize travel and optimize ...
Oyegoke Teslim Bukoye, Sathvik Gadiraju
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Data Source Importance Evaluation for Highway Networks: A Complex Network-Based Approach

Promet (Zagreb)
Data collection technologies or data sources are critical for highway network management. However, due to the limitations on available management resources, determining the importance of these data sources is necessary to allocate these resources ...
Huangqin HUANG, Jianhua GUO, Xiangyu SHI, Leixiao SHEN   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A personalized recommendation system for multi-modal transportation systems

Multimodal Transportation, 2022
Recommendation system has recently experienced widespread applications in fields like advertising and streaming platforms. Its ability of extracting valuable information from complex data makes it a promising tool for multi-modal transportation system ...
Fanyou Wu, Cheng Lyu, Yang Liu
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

LEGAL ASPECTS OF MULTIMODAL TRANSPORTATION: A TURKISH APPROACH IN MULTIMODAL TRANSPORT PROBLEMS

, 2015
Karma taşıma yükü birden fazla taşıma modu kullanarak bir yerden başka bir yere sevketmektir. Karma taşıma zinciri hava, kara ve deniz taşıma modlarını birbirine bağlayıp tek bir mod altında toplayarak etkili, uygun maliyetli, çevreye duyarlı bir şekilde karma taşıma operatörü olarak bilinen tek bir taşıma operatörünün sorumluluğunda kapıdan kapıya ...
openaire   +4 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Modeling the adoption of urban air mobility based on technology acceptance and risk perception theories: A case study on flying cars

Multimodal Transportation
Flying cars, a symbol of Urban Air Mobility (UAM), signify a pivotal step in revolutionizing urban transportation and play a pivotal role in shaping future transport systems.
Sangen Hu, Zikang Huang, Ke Wang, Haiyuan Lin, Mingyang Pei   +4 more
doaj   +1 more source