Results 241 to 250 of about 84,209 (281)

Quantification of Age and Sex Ratio Differences between Trial and Target Population for New Drugs

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1105-1111, April 2026.
Clinical trials are essential to understand the benefit‐harm profile of new drugs. Lack of adequate representation in age and sex ratio in clinical trials can result, for example, in higher side effects for underrepresented patients. We quantified differences in age and sex ratios between trial and target populations of new drugs approved by the FDA ...
Miquel Serra‐Burriel, Paul Schlossmacher, Kerstin Noelle Vokinger   +2 more
wiley   +1 more source

Regional Patterns of Multimorbidity and Hospitalization in Saskatchewan's Aging Population. [PDF]

Healthcare (Basel)
Okpalauwaekwe U, Rana M, Tzeng HM.
europepmc   +1 more source

Genomic signature driving preinvasive to invasive processes in stage I lung adenocarcinoma

International Journal of Cancer, Volume 158, Issue 7, Page 1975-1988, 1 April 2026.
What's new? The progression of lung cancer from minimally invasive adenocarcinoma (MIA) to invasive adenocarcinoma (IA) is a complex process involving molecular and microenvironment changes. Key molecular events that drive the invasion process, however, remain poorly characterized. In this comparison of gene profiles and differentially mutated genes in
Biqin Mou, Yishan Duan, Jing Wang, Tiantian Li, Yuwei Huo, Xia Xiao, Conghui Cui, Zhujun Deng, Qiongxia Hu, Juan Jiang, Yiwei Liang, Sifen Lu, Xintong Tao, Kang Xie, Xinru Xiong, Niu Zhu, Liyun Bi, Faqiang Zhang, Weimin Li, Bojiang Chen   +19 more
wiley   +1 more source

Reframing TB Care: A Perspective on Multimorbidity-Centered Care for People with TB. [PDF]

Trop Med Infect Dis
Tabackman A, Cowan S, Calderwood C, Sinha P.   +3 more
europepmc   +1 more source

IgA Antibodies Reveal Covert Infection With Mpox Virus in People Living With HIV in the Community: A Prospective Longitudinal Cohort Survey

MedComm, Volume 7, Issue 4, April 2026.
This study identified covert infection of MPXV among people living with HIV and MPXV‐IgA was the effective indicator. The combined use of two antigen protein set of MPXV (B6R plus E8L and E8L plus H3L) yield IgA test results comparable to those obtained with the MPXV.
Rui Song, Danyang Li, Lan Chen, Xiao Wang, Qiao Zhang, Zhixia Gu, Xueqi Chi, Yuanyuan Zhang, Jing Han, Li Guo, Ronghua Jin, Lili Ren, Jianwei Wang   +12 more
wiley   +1 more source

Youth stress, happiness, and life satisfaction across morbidity status: a gender-stratified analysis. [PDF]

Sci Rep
Ferro MA, Luther A, Fearon D, Dubin JA, Duncan L, Leatherdale ST, Browne DT, Colman I.   +7 more
europepmc   +1 more source

Pilot study on the use of a multimorbidity index in patients receiving home parenteral nutrition

Nutrition in Clinical Practice, Volume 41, Issue 2, Page 554-561, April 2026.
Abstract Background Home parenteral nutrition (HPN) patients often have multiple comorbidities. A validated multimorbidity index (MMI) could help determine resource needs and risks with HPN. We evaluated MMI scoring to determine if it predicted HPN resource use and outcomes.
Michael M. Rothkopf, Mohan Pant, Zachary Rothkopf, Rebecca Brown, Jamie Haselhorst, Debbie L. Stevenson, Andrew DePalma, Michael Saracco   +7 more
wiley   +1 more source

The Impact of a Health Coaching App on the Subjective Well-Being of Individuals With Multimorbidity: Mixed Methods Study. [PDF]

J Med Internet Res
Symes I, Burton A, Mercado D, Bu F.
europepmc   +1 more source

The Future of the Obesity Management Landscape: Challenges, Opportunities and Solutions

Obesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Objective In July 2023 a diverse group of international experts from academia, healthcare and medical technology/pharmacological companies gathered to discuss the current global landscape in the management of obesity, identify the clinical challenges healthcare systems are facing, and the gaps in scientific knowledge. Approach We proposed ways
Alexander Dimitri Miras, Alexander Kokkinos, Abd Tahrani, Ricardo Reynoso, Jörg Tomaszewski, Ildiko Lingvay, Domenica Rubino, Jonathan Q. Purnell, Muzamil Hussain, Amy Hall, Dimitrios Pournaras, Philip Schauer, Carel W. le Roux, Luiza Borowska, Chiedza Kaitano, Ishita Doshi, Dominique Gregoire, Helen Haggart, María Morán Gortaire, Stephanie Mutchler, Barbara Sleypen, Elena Startseva, Priya Sumithran, Francis M. Finucane   +23 more
wiley   +1 more source

Multimorbidity patterns in elderly sleep disordered breathing patients. [PDF]

ERJ Open Res
Suusgaard J, Christiansen CB, Lambert MK, Hashiba M, Ibsen M, Ibsen R, Kjellberg J, Jennum PJ.   +7 more
europepmc   +1 more source