Results 111 to 120 of about 17,499,756 (289)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Classical -Quantum Multiple Access Channel with Secrecy Constraint: One-shot Rate Region

International Journal of Information and Communication Technology Research, 2020
In this paper, we aim to study a -user quantum multiple access wiretap channel with an arbitrary number of wiretappers under one-shot setting. In this regard, we first introduce the general quantum multiple access wiretap channel and the simplified ...
Hadi Aghaee, Bahareh Akhbari
doaj  

Stability and Delay of NDMA-MPR Protocol in Rice-Correlated Channels with Co-Channel Interference

Technologies, 2019
This paper investigates backlog retransmission strategies for a class of random access protocols with retransmission diversity (i.e., network diversity multiple access or NDMA) combined with multiple-antenna-based multi-packet reception (MPR). This paper
Ramiro Sámano-Robles
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

On the Trade-off Between Spectrum Efficiency with Dedicated Access and Short End-to-End Transmission Delays with Random Access in DVB-RCS2 [PDF]

, 2013
This paper analyses the performance of TCP over random and dedicated access methods in the context of DVB-RCS2. Random access methods introduce a lower connection delay compared to dedicated methods.
Emmanuel Lochin, José Radzik, Bui, Huyen Chi, Lacan, Jérôme, Lochin, Emmanuel, Nicolas Kuhn, Radzik, José, Huyen-Chi Bui, Kuhn, Nicolas, Jérôme Lacan   +9 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Multi-channel Dual Clocks three-dimensional probability Random Multiple Access protocol for Wireless Public Bus Networks based on RTS/CTS mechanism

MATEC Web of Conferences, 2016
A MAC protocol for public bus networks, called Bus MAC protocol, designed to provide high quality Internet service for bus passengers. The paper proposed a multi-channel dual clocks three-demission probability random multiple access protocol based on RTS/
Zhou Sheng Jie, Ding Hong Wei, Wang Meng Yao, Liu Qian Lin, Yang Zhi Jun   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source