Results 121 to 130 of about 1,087,662 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Parameter-masked Mock Data Challenge for Beyond-two-point Galaxy Clustering Statistics

The Astrophysical Journal
The past few years have seen the emergence of a wide array of novel techniques for analyzing high-precision data from upcoming galaxy surveys, which aim to extend the statistical analysis of galaxy clustering data beyond the linear regime and the ...
The Beyond-2pt Collaboration, Elisabeth Krause, Yosuke Kobayashi, Andrés N. Salcedo, Mikhail M. Ivanov, Tom Abel, Kazuyuki Akitsu, Raul E. Angulo, Giovanni Cabass, Sofia Contarini, Carolina Cuesta-Lazaro, ChangHoon Hahn, Nico Hamaus, Donghui Jeong, Chirag Modi, Nhat-Minh Nguyen, Takahiro Nishimichi, Enrique Paillas, Marcos Pellejero Ibañez, Oliver H. E. Philcox, Alice Pisani, Fabian Schmidt, Satoshi Tanaka, Giovanni Verza, Sihan Yuan, Matteo Zennaro   +25 more
doaj   +1 more source

Fitting complex ecological point process models with integrated nested Laplace approximation

, 2013
Summary 1. We highlight an emerging statistical method, integrated nested Laplace approximation (INLA), which is ideally suited for fitting complex models to many of the rich spatial data sets that ecologists wish to analyse. 2.
Gallego-Fernández, Juan B., Travis, Justin M. J., Illian, Janine Baerbel, Esquivias, M. Paz, Martino, Sara, Zunzunegui, Maria, Illian, Janine B., Warton, David, Sørbye, Sigrunn H., Travis, Justin M.   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Optimisation issues in 3D multiple-point statistics simulation

, 2008
, 2008Multiple-point statistics simulation has gained wide acceptance in recent years and is routinely used for simulating geological heterogeneity in hydrocarbon reservoirs and aquifers.
Froidevaux, Roland, Renard, Philippe, Walgenwitz, Alexandre, Besson, Olivier, Straubhaar, Julien   +4 more
core  

Functional summary statistics and testing for independence in multi-type point processes on the surface of three dimensional convex shapes

The fundamental functional summary statistics used for studying spatial point patterns are developed for marked homogeneous and inhomogeneous point processes on the surface of a sphere.
Ward, Scott, Adams, Niall, Cohen, Edward
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Influence of digital technology on selected SMEs in Anambra state, Nigeria: Does digital technologies impact on SMEs?

International Journal of Applied Research in Business and Management
The study examined the influence of digital technology on selected small and medium-sized enterprises in Anambra State, Nigeria. The specific objectives are to; examine the effects of social media marketing tools on the performance of selected SMEs and ...
Dr Happiness Ifunanya Anusi
doaj   +1 more source