Results 41 to 50 of about 817,699 (342)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Modular decomposition of the NOR-TSUM multiple-valued PLA [PDF]
, 1997 A method for designing PLA-based combinational circuits by modular decomposition is presented. Main subjects are 1) Specific properties of TSUM operator, 2) MIN-TSUM and NOR-TSUM expansions with respect to the bound set, X1 of variables, 3) Realization ...
Kalganova, T +2 more
core
Finding Attractors in Synchronous Multiple-Valued Networks Using SAT-Based Bounded Model Checking [PDF]
, 2010 Synchronous multiple-valued networks are a discrete-space discrete-time model of the gene regulatory network of living cells. In this model, cell types are represented by the cycles in the state transition graph of a network, called attractors.
Elena Dubrova +5 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Novel Ternary Adder and Multiplier Designs Without Using Decoders or Encoders
IEEE Access, 2021 Multiple-Valued Logic systems present significant improvements in terms of energy consumption over binary logic systems. This paper proposes new ternary combinational digital circuits that reduce energy consumption in low-power nano-scale embedded ...
Jihad Mohamed Aljaam +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Smart universal multiple-valued logic gates by transferring single electrons [PDF]
, 2008 This paper proposes smart universal multiple-valued (MV) logic gates by transferring single electrons (SEs). The logic gates are based on MOSFET based SE turnstiles that can accurately transfer SEs with high speed at high temperature.
nanjian@red.semi.ac.cn +3 more
core
Graded Many-Valued Modal Logic and Its Graded Rough Truth [PDF]
, 2022 Much attention is focused on the relationship between rough sets and many-valued modal logic to deal with approximate reasoning. This paper discusses the graded modal logic and puts forward the graded many-valued modal logic G(S5). Secondly, by employing
Zengtai Gong, Jiansheng Li
core +1 more source