Results 121 to 130 of about 7,099,925 (317)

Acinetobacter spp. in Gunshot Injuries

open access: yesEmerging Infectious Diseases, 2008
James W.T. Elston   +3 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

INTERRELATION OF THE LOCALIZATION OF FOCI OF DEMYELINATION WITH THE SEVERITY OF COGNITIVE IMPAIRMENT IN PATIENTS WITH MULTIPLE SCLEROSIS

open access: yesАктуальні проблеми сучасної медицини, 2019
Most investigation of the multiple sclerosis are devoted to the study of motor and sensory disorders. However, patients also are worried about cognitive impairment, which manifests in memory impairment, attention and reduced working capacity.
Djamilya Aravitskaya, Vladimir Dariy
doaj  

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Matematica e ontologia in Alain Badiou [PDF]

open access: yesKaiak
Badiou’s philosophical project is to outline the Number as the resource of Being within the limits of a situation, the ontological or mathematical situation.
Giorgio Rizzo
doaj  

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

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