Results 151 to 160 of about 7,099,925 (317)
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho+11 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source
Patterns of multimorbidity in older adults with multiple myeloma: An analysis of SEER-Medicare. [PDF]
Oyinbo AG+7 more
europepmc +1 more source
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau+9 more
wiley +1 more source
Multiplication cubes and multiplication automata
AbstractWe extend previously known two-dimensional multiplication tiling systems that simulate multiplication by two natural numbers p and q in base $pq$ to higher dimensional multiplication tessellation systems. We develop the theory of these systems and link different multiplication tessellation systems with each other via macrotile operations that
openaire +2 more sources
Multiple high-risk human papillomavirus infections exacerbate cervical lesion risk: epidemiological evidence from suining, Sichuan. [PDF]
Jing Y+9 more
europepmc +1 more source
MULTIPLE DEGENERATIVE SOFTENING VERSUS MULTIPLE SCLEROSIS [PDF]
George B. Hassin
openalex +1 more source