Results 261 to 270 of about 10,043,163 (317)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CNS Involvement of Multiple Myeloma-A Case Series and Narrative Literature Review. [PDF]

J Clin Med
Andrunache A, Himcinschi ME, Barbu S, Zidaru LE, Alexa D, Popescu M, Apuscaroaie SM, Popa DC, Ursuleac I, Coriu D, Badelita SN.   +10 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Defining Activity-Based Subgroups in Multiple Sclerosis: A Review and Framework Proposal. [PDF]

Eur J Neurol
Lopez Manzano C, Rice CM, Tallantyre E, Cooper C, Wang H, Tomlinson E, Sadek A, Rao-Middleton A, Thom H, Whiting P.   +9 more
europepmc   +1 more source

Multiple Leiomyomata

Infectious Diseases in Obstetrics and Gynecology, 1997
openaire   +2 more sources

Torsional Stability of the Femoral Neck System for Pauwels Type III Femoral Neck Fracture Fixation: A Finite-element Analysis. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Chantarapanich N, Jitprapaikulsarn S, Mahaisavariya B, Mahaisavariya C.   +3 more
europepmc   +1 more source

Comparative Effectiveness of Single-Dose vs. Multi-Dose Prophylactic Antibiotics in Reducing Post-Surgical Infections: A Systematic Review and Meta-Analysis. [PDF]

Int J Microbiol
Khan S, Amro M, Khalidi M, Sultana S, Pereira M, El Said M.   +5 more
europepmc   +1 more source

Multiple sources and student engagement in the smart classroom: the mediating role of foreign language enjoyment under control-value theory. [PDF]

Front Psychol
Wu J.
europepmc   +1 more source