Results 31 to 40 of about 7,742,036 (343)

Fatigue in multiple sclerosis is associated with multimodal interoceptive abnormalities

Multiple Sclerosis, 2019
Background: Fatigue ranks among the most common and disabling symptoms in multiple sclerosis (MS). Recent theoretical works have surmised that this trait might be related to alterations across interoceptive mechanisms.
Cecilia González Campo, Paula Salamone, Nicolás Rodríguez-Arriagada, Fabian Richter, Eduar Herrera, D. Bruno, Fátima Pagani Cassará, V. Sinay, Adolfo M. García, A. Ibáñez, Lucas Sedeño   +10 more
semanticscholar   +1 more source

Clinical Significance of TP53 Abnormalities in Newly Diagnosed Multiple Myeloma

Turkish Journal of Hematology, 2021
Objective: This study aimed to identify the clinical significance of TP53 and common cytogenetic abnormalities. Materials and Methods: A total of 114 patients with newly diagnosed multiple myeloma (MM) and TP53 abnormalities were selected from two large ...
Fang Ye, Tongtong Wang, Aijun Liu, Yanchen Li, Ningning Li, Huan Wang, Wenming Chen   +6 more
doaj   +1 more source

Lipid Profile Abnormalities in ß-Thalassemia Patients with Multiple Blood Transfusions

Journal of Bahria University Medical and Dental College, 2023
Objective: To determine lipid profile abnormalities in ß -thalassemia patients with multiple blood transfusions in tertiary care hospital.   Study design and setting: This cross-sectional study was conducted in Chemical Pathology section ...
Syeda Sabahat Haidar, Mehvish Sana, Rukhsana Tumrani, Farwa Shafqat   +3 more
doaj   +1 more source

An aberrant bald eagle (Haliaeetus leucocephalus) with multiple anatomical abnormalities

Vertebrate Anatomy, Morphology, Palaeontology, 2019
Genetic abnormalities, especially polydactyly, are quite common among birds. Although there are numerous accounts of anatomically abnormal birds with polydactyly, few written anatomical descriptions have elucidated whether or not these physical ...
Jeremy Klingler, Christine Glasmann
doaj   +3 more sources

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Colour Vision Abnormalities in Multiple Sclerosis [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1987
ABSTRACT:A battery of colour vision tests was employed to evaluate visual function in patients with multiple sclerosis (M.S.). Colour deficits were found in 45% of patients tested with the Ishihara plates and 42.5% of patients tested with the FM 100-Hue test. 65% of M.S.
A C, Harrison, W J, Becker, W K, Stell
openaire   +2 more sources

Prognostic implications of abnormalities of chromosome 13 and the presence of multiple cytogenetic high-risk abnormalities in newly diagnosed multiple myeloma

Blood Cancer Journal, 2017
Fluorescence in situ hybridization evaluation is essential for initial risk stratification in multiple myeloma. While the presence of specific cytogenetic high-risk abnormalities (HRA) is known to confer a poor prognosis, less is known about the ...
M. Binder, S. Rajkumar, R. Ketterling, P. Greipp, A. Dispenzieri, M. Lacy, M. Gertz, F. Buadi, S. Hayman, Y. Hwa, S. Zeldenrust, J. Lust, S. Russell, N. Leung, P. Kapoor, R. Go, W. Gonsalves, R. Kyle, S. Kumar   +18 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source