Results 61 to 70 of about 1,089,170 (344)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]

, 2006
Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko, Morishima, Tsuneo, Ninomiya, Shinsuke, Shinozuka, Masako, Une, Tomoka, Yokoyama, Yuji   +5 more
core   +1 more source

Long-term multiple metabolic abnormalities among healthy and high-risk people following nonsevere COVID-19

Scientific Reports, 2023
Few studies have identified the metabolic consequences of the post-acute phase of nonsevere COVID-19. This prospective study examined metabolic outcomes and associated factors in nonsevere, RT-PCR-confirmed COVID-19.
Chaiwat Washirasaksiri, Naruemit Sayabovorn, Pinyapat Ariyakunaphan, Chayanis Kositamongkol, Thanet Chaisathaphol, Tullaya Sitasuwan, Rungsima Tinmanee, Chonticha Auesomwang, Pongpol Nimitpunya, Diana Woradetsittichai, Methee Chayakulkeeree, Pakpoom Phoompoung, Korapat Mayurasakorn, Nitat Sookrung, Anchalee Tungtrongchitr, Rungsima Wanitphakdeedecha, Saipin Muangman, Sansnee Senawong, Watip Tangjittipokin, Gornmigar Sanpawitayakul, Cherdchai Nopmaneejumruslers, Visit Vamvanij, Pochamana Phisalprapa, Weerachai Srivanichakorn   +23 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Characterization of an Inherited Neurologic Syndrome in Toyger Cats with Forebrain Commissural Malformations, Ventriculomegaly and Interhemispheric Cysts. [PDF]

, 2016
BackgroundIn children, frequent congenital malformations with concomitant agenesis of the corpus callosum are diagnosed by neuroimaging in association with other cerebral malformations, including interhemispheric cysts and ventriculomegaly.
Creighton, EK, Keating, MK, Lyons, LA, Sisó, S, Sturges, BK, Wisner, ER   +5 more
core  

Role of fetal MRI in the evaluation of isolated and non-isolated corpus callosum dysgenesis: results of a cross-sectional study [PDF]

, 2017
PURPOSE: The aims of this study were to characterize isolated and non-isolated forms of corpus callosum dysgenesis (CCD) at fetal magnetic resonance imaging (MRI) and to identify early predictors of associated anomalies.
Antonelli, Amanda, Bernardo, Silvia, Catalano, Carlo, DE VITO, Corrado, Di Meglio, L, Giancotti, Antonella, Manganaro, Lucia, Marchionni, Enrica, Pizzuti, Antonio, Saldari, Matteo, Silvestri, E, Vinci, Valeria   +11 more
core   +1 more source

Multiple Myeloma Immunophenotype Related to Chromosomal Abnormalities Used in Risk Assessment

Diagnostics, 2022
(1) Background: At diagnosis, multiplemyeloma risk estimation includes disease burden, end-organ damage, and biomarkers, with increasing emphasis on genetic abnormalities. Multicolor flow cytometry (MFC) is not always considered in risk estimation.
Mantas Radzevičius, Vaidas Dirsė, Indrė Klimienė, Rėda Matuzevičienė, Zita Aušrelė Kučinskienė, Valdas Pečeliūnas   +5 more
doaj   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Bandit Models of Human Behavior: Reward Processing in Mental Disorders

, 2017
Drawing an inspiration from behavioral studies of human decision making, we propose here a general parametric framework for multi-armed bandit problem, which extends the standard Thompson Sampling approach to incorporate reward processing biases ...
A Dezfouli, AD Redish, AM Taylor, D Bouneffouf, D Bouneffouf, DC Perry, LE Hess, M Luman, MJ Frank, P Auer, P Auer, P Auer, TL Lai, TU Hauser, W Thompson, WR Thompson, WW Seeley   +16 more
core   +1 more source

Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients

Frontiers in Neurology, 2017
BackgroundCognitive fatigue and autonomic abnormalities are frequent symptoms in MS. Our model of MS-related fatigue assumes a shared neural network for cognitive fatigue and autonomic failures, i.e., aberrant vagus nerve activity induced by inflammatory
Carina Sander, Carina Sander, Helmut Hildebrandt, Helmut Hildebrandt, Hans-Peter Schlake, Paul Eling, Katrin Hanken, Katrin Hanken   +7 more
doaj   +1 more source