Results 181 to 190 of about 106,714 (307)

Predicting high dengue incidence in municipalities of Brazil using path signatures. [PDF]

Sci Rep
Villela DAM.
europepmc   +1 more source

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source

Adolescent literacy, trust, and acceptance of vaccines before and after educational intervention: protocol for a mixed methods research. [PDF]

BMC Public Health
de Freitas BHBM, Lima JC, Sartori AL, Haeffner R, Nemer CRB, da Silva ARV, Sales CMM, Garcia EM, Bortolini J, Ratzan SC.   +9 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Rural multidimensional poverty and livelihood mix: A micro level study in Bihar, India. [PDF]

Heliyon
Onyeyirichi OA, Deepika MG.
europepmc   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Seeking consensus on dilemmas related to euthanasia in dementia based on an advance directive: a Delphi study from a medical, ethical and legal perspective. [PDF]

J Med Ethics
de Boer ME, Coers DO, Sizoo EM, Ten Bokkel Huinink DMJ, Leget CJW, Hertogh CMPM, DALT project group.   +6 more
europepmc   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Launching a Village to promote aging in community: human, social, and financial capital. [PDF]

Front Public Health
Greenfield EA.
europepmc   +1 more source

Polarization‐Dependent 3D Holography Generated by Inverse Design Nanoprinting Metasurface

Advanced Science, EarlyView.
A novel polarization‐dependent 3D holography is proposed by introducing polarization as an additional freedom, enabling enhanced depth selectivity and greater control over holographic reconstruction. The efforts perfectly combine the polarization and 3D holography display into ADAM gradient descent algorithm, the application of nanoprinting further ...
Lingxing Xiong, Jintao Gong, Fei Zhang, Wenhao Miao, Qiong He, Dapeng Zhang, Yangjian Cai, Nan Chi   +7 more
wiley   +1 more source