Results 41 to 50 of about 106,714 (307)

The Multiple Effects of Capital Controls

Comparative Economic Research. Central and Eastern Europe, 2020
Capital controls are seen as a means to promote financial stability or improve macroeconomic adjustment in economies with nominal rigidities and suboptimal monetary policy. Such controls may take various forms, including explicit or implicit taxation of cross‑border financial flows and dual or multiple exchange rate systems.
openaire   +6 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Planning and Leveraging Event Portfolios: Towards a Holistic Theory [PDF]

, 2013
This conceptual paper seeks to advance the discourse on the leveraging and legacies of events by examining the planning, management, and leveraging of event portfolios.
Boorstin D., Bourdieu P., Chalip L., Clark K. B., Coleman J. S., Elton E. J., Garcia B., Geertz C., Getz D., Glover T. D., Green G. P., Haig B. D., Hall C. M., Handelman D., Hemingway J. L., Henderson B. D., Kilduff M., Laumann E. O., Layder D., Lipton P., Mangan J. A., Parent M. M., Picard D., Prasad D., Putnam R. D., Richards G., Rohe W. M., Sack A. L., Scott J., Sharpley R., Smith A., Turner V., Vassilios Ziakas, Weed M., Weed M., Ziakas V.   +35 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

FINANCING THE SOCIAL ENTERPRISE: SUSTAINABLE GROWTH THROUGH SUSTAINABLE GIVING [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
A social enterprise is a business with specific social objectives. Like every business endeavor, it is built on a commercial framework, yet the social enterprise aims to make – besides its money-making purpose - a powerful social, and environmental ...
URECHE ALEXANDRU
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Field, Habitus and Capitals from Narratives of Unemployed Men with Families

Masculinities and Social Change
This article proposes as a transversal axis the analysis of masculinity in unemployed men with families. The aim of this article is to analyse the connotations of field, habitus and capitals based on the narratives of unemployed men with families.
Giovane Mendieta-Izquierdo, Carlos José Monrroy-Barrero, Juan María Cuevas-Silva   +2 more
doaj   +3 more sources

Sustainable economic growth within environmental limits. volume 1: guidance for the east midlands [PDF]

, 2010
LUC and GHK have developed a tool for setting environmental limits that local communities and other stakeholders can use. The three-step approach is based on the participation of the local community and other interested stakeholders, such as statutory ...
GHK Consulting, Land Use Consultants
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A virada das mobilidades: fluxos, fixos e fricções

Revista Crítica de Ciências Sociais, 2020
At least since the 2000s, we have witnessed the effort to understand, in multiple disciplinary fields and from different empirical realities, the complexity of the interdependent movement of people and capitals, images and goods.
Bianca Freire-Medeiros, Mauricio Piatti Lages   +1 more
doaj   +1 more source