Results 141 to 150 of about 736,185 (247)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Multiple causes of death analysis of chronic diseases: the example of diabetes. [PDF]
Popul Health Metr, 2015 Fedeli U +5 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Growing burden of sepsis-related mortality in northeastern Italy: a multiple causes of death analysis. [PDF]
BMC Infect Dis, 2016 Fedeli U +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
What can multiple causes of death tell about cardiovascular mortality during COVID-19 pandemic in the United States? [PDF]
J Public Health (Oxf)Ukolova E, Burcin B.
europepmc +1 more source
Mortality associated with hepatitis C and hepatitis B virus infection: A nationwide study on multiple causes of death data. [PDF]
World J Gastroenterol, 2017 Fedeli U, Grande E, Grippo F, Frova L.
europepmc +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Reassessing the Link between Airborne Arsenic Exposure among Anaconda Copper Smelter Workers and Multiple Causes of Death Using the Parametric g-Formula. [PDF]
Environ Health Perspect, 2017 Keil AP, Richardson DB.
europepmc +1 more source