Results 71 to 80 of about 3,106,842 (264)

Dynamic Characteristics of Magnetorheological Mounted Metal Rubber Structures Under Multi-physics Coupling Conditions

Medžiagotyra
To accurately predict the dynamic characteristics of MR mounting, the nonlinear electromagnetic coupling law between MR liquid and soft magnetic material and the solid-liquid interaction, the electromagnetic coupling and fluid-structure coupling ...
Bo PENG, Jintao SU, Jinquan NIE
doaj   +1 more source

Avalanche multiplication characteristics of Al0.8Ga0.2As diodes \ud [PDF]

, 2001
The avalanche multiplication characteristics of Al0.8Ga 0.2As have been investigated in a series of p-i-n and n-i-p diodes with i-region widths, w, varying from 1 μm to 0.025 μm. The electron ionization coefficient, α, is found to be consistently higher than the hole ionization coefficient, β, over the entire range of electric fields investigated.
Ng, B.K., David, J.P.R., Plimmer, S.A., Rees, G.J., Tozer, R.C., Hopkinson, M., Hill, G.   +6 more
openaire   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Characteristics of 263K Scrapie Agent in Multiple Hamster Species

Emerging Infectious Diseases, 2009
Transmissible spongiform encephalopathy (TSE) diseases are known to cross species barriers, but the pathologic and biochemical changes that occur during transmission are not well understood.
Kimberly D. Meade-White, Kent D. Barbian, Brent Race, Cynthia Favara, Don Gardner, Lara Taubner, Stephen Porcella, Richard Race   +7 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis of clinical characteristics, treatment response, and prognosis among 67 patients with anaplastic multiple myeloma

World Journal of Surgical Oncology
Background Anaplastic multiple myeloma (AMM) is a type of distinctive MM with a poor prognosis. AMM is mostly reported as individual cases, an accurate incidence and strict clinical definition are lacking.
Fei Chen, Yan Wang, Zhongxia Huang, Man Qi, Hong Chen   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple Focal Nodular Hyperplasia and Steatohepatitis: Atypical Imaging Characteristics

Canadian Journal of Gastroenterology, 2001
Focal nodular hyperplasia is a rare, benign condition of the liver. A 28-year-old woman with malignant melanoma, mild liver enzyme abnormalities, steatohepatitis and newly documented hepatic lesions is described.
Robert P Myers, Dónal Downey, Subrata Chakrabarti, Paul J Marotta   +3 more
doaj   +1 more source