Results 111 to 120 of about 1,232,214 (293)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The computational complexity of boundedly rational choice behavior [PDF]

open access: yes
This research examines the computational complexity of two boundedly rational choice models that use multiple rationales to explain observed choice behavior.
Thomas DEMUYNCK
core  

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, Volume 600, Issue 12, Page 1729-1743, June 2026.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Clusters of response behavior in time-limited multiple-choice intelligence testing

open access: yes, 2017
Raw scores on time-limited multiple-choice intelligence tests are determined by two error types: incorrect responses and errors of omission. The aim of the present study was to search for different clusters of response behavior based on these two error ...
Rammsayer, Thomas   +2 more
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Efficient availability stated choice designs

open access: yes, 2013
In stated choice studies it is common to present in multiple alternatives to respondents with varying levels of the attributes over a series of choice tasks. Typically all (labelled) alternatives are presented in each choice task.
Rose, J.M.   +2 more
core  

Group versus modified individual standard-setting on multiple-choice questions with the Angoff method for fourth-year medical students in the internal medicine clerkship

open access: yesAdvances in Medical Education and Practice, 2013
Vichai Senthong,1,* Jarin Chindaprasirt,1,* Kittisak Sawanyawisuth,1 Noppadol Aekphachaisawat,2 Suteeraporn Chaowattanapanit,1 Panita Limpawattana,1 Charoen Choonhakarn,1 Aumkhae Sookprasert1 1Department of Medicine, Faculty of Medicine, Khon Kaen ...
Senthong V   +7 more
doaj  

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