Results 181 to 190 of about 3,439,145 (349)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Podophyllotoxin sensitizes triple-negative breast cancer cells to CD47-targeted immunotherapy. [PDF]

Cell Insight
Dang J, Song N, Zhou J, Raoof M, Feng M.
europepmc   +1 more source

One-way ANOVA and Tukey's multiple comparison test results for MTT and antioxidant data

Van der Merwe, Breyten
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Replication challenges in linking personality to resting-state functional connectomics. [PDF]

Front Comput Neurosci
Jajcay N, Tomeček D, Fajnerová I, Rydlo J, Tintěra J, Horáček J, Lukavský J, Hlinka J.   +7 more
europepmc   +1 more source

Testing homogeneity of effect sizes in pooling 2x2 contingency tables from multiple studies: a comparison of methods

, 2018
Osama Almalik, Edwin R. van den Heuvel
openalex   +1 more source

Analysis goals, error‐cost sensitivity, and analysis hacking: Essential considerations in hypothesis testing and multiple comparisons [PDF]

, 2020
Sander Greenland
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Coexisting in a Crowded Field: A 10-year Comparison of Procedural Volumes of Plastic Surgeons and Other Surgical Specialties in the United States. [PDF]

Arch Plast Surg
MacKenzie EL, Orgun D, Matabele KLW, Poore SO.   +3 more
europepmc   +1 more source

Comparison of Force and Moment Coefficients for the Same Test Article in Multiple Wind Tunnels

, 2013
Richard DeLoach
openalex   +1 more source