Results 241 to 250 of about 3,439,145 (349)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Serum tumor markers combined with HRCT for malignancy risk assessment of solitary pulmonary nodules: a retrospective study. [PDF]

Front Genet
Zhou Y, Wang S, Zhang Y.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Healthcare utilization and cost analysis by social determinants of health: a prospective cohort study in Catalonia, Spain. [PDF]

BMC Health Serv Res
Rodoreda-Pallàs B, Morín-Fraile V, Fuster-Casanovas A, Miró Catalina Q, Vidal-Alaball J, Velasco-Márquez E, Sola Reguant L, Musarra Carvajal L, Mas Comas G, Lumillo-Gutierrez I.   +9 more
europepmc   +1 more source

A SEQUENTIAL MULTIPLE COMPARISON PROCEDURE FOR DETECTING A LOWEST DOSE HAVING INTERACTION IN A DOSE-RESPONSE TEST

, 2015
Tomohiro Nakamura, Hideyuki Douke
openalex   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Cognitive screening biases in a secondary prevention Alzheimer's disease clinical trial. [PDF]

Alzheimers Dement
Sai I, Grill JD, Younes K, Winer JR, Cody KA, Sperling R, Mormino EC, Young CB.   +7 more
europepmc   +1 more source

Additional file 6 of A multiple testing procedure for multi-dimensional pairwise comparisons with application to gene expression studies

, 2016
Anjana Grandhi, Wenge Guo, Shyamal Peddada   +2 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source