Results 241 to 250 of about 1,773,114 (300)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Publisher Correction: The CNP analogue vosoritide mediates PDE2-sensitive anti-arrhythmogenic effects in mouse hearts with STZ-induced type 1 diabetes. [PDF]

Basic Res Cardiol
Firneburg R, Tergau K, Cachorro E, Schubert M, Dhara A, Luo X, Klapproth E, Guan K, El-Armouche A, Kämmerer S.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

KLF2 alleviates sepsis-induced acute kidney injury via the lncRNA GAS6-AS2/GOLPH3 axis. [PDF]

BMC Nephrol
Feng W, Zhu YF, Li KY, Xu XS, Zhang BY, Zhou J.   +5 more
europepmc   +1 more source

Genetic interaction of <i>DISC1</i> and <i>Neuroligin</i> in regulation of glutamatergic synaptogenesis. [PDF]

Front Neurosci
Honda T, Pandey H, Sawa A, Furukubo-Tokunaga K.   +3 more
europepmc   +1 more source

Correction: Cell-free mitochondrial DNA as a potential predictor for hypoxic stress. [PDF]

Mol Biol Rep
Qu Q, Xiao C, Liu X, Huang A, Li H, Xu G, Shao N, Zhao Y, Gao B.   +8 more
europepmc   +1 more source

SLX4IP limits replication stress globally and at ALT telomeres. [PDF]

EMBO J
Spindler J, Pandolfo F, Koch AE, Piccirillo P, Jordahl D, Venkatesh N, Suresh D, Ylvisaker KR, Jopkiewicz A, Bihler J, Buschbaum S, Morgenstern M, Overmyer KA, Vincendeau E, Coon JJ, Wei PC, Hänsel-Hertsch R, Mehta KPM, Panier S.   +18 more
europepmc   +1 more source

PPIL2 suppression induces cellular senescence and inhibits proliferation in hepatocellular carcinoma via c-myc/p21 axis. [PDF]

J Biol Chem
Chen X, Zhang Z, Yan Z, Du X, Wang J, Liu X, Hu L, Kuang Z, He K, Zhang J, Han Y.   +10 more
europepmc   +1 more source