Results 231 to 240 of about 200,390 (295)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Dynamic Modeling and Analysis of Rotary Joints with Coupled Bearing Tilt-Misalignment Faults. [PDF]

Entropy (Basel)
Lu J, Zhu Z, Ji J, Yang Y, Miao X, Yan X, Liu Q.   +6 more
europepmc   +1 more source

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

Study of power quality issues without and with Microgrid in Egypt. [PDF]

Sci Rep
Abdelsattar M, Aly MM, Abu-Elwfa SS.
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Spin dynamics in elemental Ni and Ni₈₅Co₁₅ thin films probed by high harmonic generated photons around the <i>M</i> _2,3 edges. [PDF]

Struct Dyn
Dubois J, Jal E, Rodriguez Cortez C, Hennes M, Delaunay R, Lambert G, Vodungbo B.   +6 more
europepmc   +1 more source

Mangrove Phenology From Scale, Data and Species Perspectives. [PDF]

Ecol Evol
Wang Y, Liu Q, Zhu Y, Wen W, Yang S, Gong M.   +5 more
europepmc   +1 more source

AI in steatohepatitis diagnostics: precision beyond the microscope. [PDF]

Ann Med Surg (Lond)
Ejaz A, Ahmed MM, Khalid M, Talha M, Waafira A.   +4 more
europepmc   +1 more source

Intelligent-based AT-SHAPF control for enhanced power quality in SOFC-driven hybrid system. [PDF]

Sci Rep
Jagadeesh Y, Kethineni B.
europepmc   +1 more source

A fully integrated harmonic injection and envelope-tracking architecture to extend the linearity of RF power amplifiers under high PAPR. [PDF]

Sci Rep
Ziraksaz F, Hassanzadeh A.
europepmc   +1 more source