Results 41 to 50 of about 2,215,776 (276)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Lasso Estimation of an Interval-Valued Multiple Regression Model
, 2015 A multiple interval-valued linear regression model considering all the cross-relationships between the mids and spreads of the intervals has been introduced recently.
A. Blanco-Fernández +6 more
core +1 more source
Simultaneous Inference in General Parametric Models [PDF]
, 2008 Simultaneous inference is a common problem in many areas of application. If multiple null hypotheses are tested simultaneously, the probability of rejecting erroneously at least one of them increases beyond the pre-specified significance level ...
Bates +29 more
core +3 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Ziraa'ah: Majalah Ilmiah Pertanian, 2022 The aim of this study is to examine the effects of land area, labor, production costs, production quantities, and prices simultaneously and partially on the income of gambier farmers in Pangkalan Koto Baru District.
Ana Tasya Rahima +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Metabolism of ticagrelor in patients with acute coronary syndromes. [PDF]
, 2018 © The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its ...
B Ibanez +41 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Using the Hybrid MLR-GA Approach for Air Pollution Forecasting [PDF]
المجلة العراقية للعلوم الاحصائية, 2019 Air Quality Modeling gained great importance in atmospheric pollution because of its negative effects on the environment and human health. In our study, the relationship between (Particulate Matter PM10) and other nine variables over three years is ...
Fanar Abdul Razaq Mohammed +1 more
doaj +1 more source