Results 91 to 100 of about 12,208,333 (235)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

On Preliminarily Exploring Multiple-Objective Capital Asset Pricing Models for the Investments of Carbon Offset: Heuristically Proving Different Tangent Planes

Mathematics
Our environment deteriorates primarily due to the emissions of carbon dioxide. Scientists and entrepreneurs promote carbon offset to reduce the emissions. Scientists and investors explore the investments of carbon offset.
Long Lin, Yue Qi
doaj   +1 more source

Probability of improvement methods for constrained multi-objective optimization [PDF]

, 2008
This paper shows how the simultaneous consideration of multiple Kriging models can lead to useful metrics for the selection of design vectors in constrained multiobjective optimization.
G.I. Hawe, Hawe, G. I., Sykulski, J. K., J.K. Sykulski   +3 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Knapsack Balancing via Multiobjectivization

Applied Sciences
In this paper, we address the aspect of knapsack balancing in the classic knapsack problem. Recognizing that excessive dispersion in the objective function or constraint coefficients of the optimal solution can be undesirable, we propose, when ...
Ignacy Kaliszewski, Janusz Miroforidis
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Analytical Shortcuts to Multiple-Objective Portfolio Optimization: Investigating the Non-Negativeness of Portfolio Weight Vectors of Equality-Constraint-Only Models and Implications for Capital Asset Pricing Models

Mathematics
Computing optimal-solution sets has long been a topic in multiple-objective optimization. Despite substantial progress, there are still research limitations in the multiple-objective portfolio optimization area.
Yue Qi, Yue Wang, Jianing Huang, Yushu Zhang   +3 more
doaj   +1 more source

On multi-objective optimization of planetary exploration rovers applied to ExoMars-type rovers [PDF]

, 2011
ExoMars is the first robotic mission of the Aurora program of the European Space Agency (EAS). Surface mobility (as provided by ExoMarks rover) is one of the enabling technologies necessary for future exploration missions.
Leite, Alexandre Carvalho
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A Constrained Multi-Objective Optimization Algorithm with a Population State Discrimination Model

Mathematics
The solution to constrained multi-objective optimization problems (CMOPs) requires optimizing the objective functions while satisfying the constraint conditions. To effectively address CMOPs, algorithms must balance objectives and constraints.
Shaoyu Zhao, Heming Jia, Yongchao Li, Qian Shi   +3 more
doaj   +1 more source