Results 31 to 40 of about 1,671 (162)

Remodeling an existing rare disease registry to be used in regulatory context: Lessons learned and recommendations

Frontiers in Pharmacology, 2022
Disease registries have been used as an interesting source of real-world data for supporting regulatory decision-making. In fact, drug studies based on registries cover pre-approval investigation, registry randomized clinical trials, and post ...
Marina Mordenti, Manila Boarini, Fabio D’Alessandro, Elena Pedrini, Manuela Locatelli, Luca Sangiorgi   +5 more
doaj   +1 more source

Real-World Data and Budget Impact Analysis (BIA): Evaluation of a Targeted Next-Generation Sequencing Diagnostic Approach in Two Orthopedic Rare Diseases

Frontiers in Pharmacology, 2022
Objective: Next-generation sequencing (NGS) technology, changing the diagnostic approach, has become essential in clinical settings, and its adoption by public health laboratories is now the practice.
Elena Pedrini, Antonella Negro, Eugenio Di Brino, Valentina Pecoraro, Camilla Sculco, Elisabetta Abelli, Maria Gnoli, Armando Magrelli, Luca Sangiorgi, Americo Cicchetti   +9 more
doaj   +1 more source

Hip Joint Osteochondroma: Systematic Review of the Literature and Report of Three Further Cases

Advances in Orthopedics, 2014
The aim of this study is to systematically review the literature with regards to surgical treatment of patients with hip joint osteochondromas, and to report our surgical management of three paediatric patients who had femoral neck or acetabular ...
Asim M. Makhdom, Fan Jiang, Reggie C. Hamdy, Thierry E. Benaroch, Martin Lavigne, Neil Saran   +5 more
doaj   +1 more source

Prevalence of Osteochondromas in the Spine in Patients with Multiple Hereditary Exostoses

JBJS Open Access
Background:. Multiple hereditary exostoses (MHE) is an autosomal-dominant disorder characterized by the development of multiple cartilage-capped exostoses originating from the physis that are known as osteochondromas.
Carlos Monroig-Rivera, MD, Lauren Bockhorn, MD, David Thornberg, BS, Brenda Santillan, BS, Karl E. Rathjen, MD   +4 more
doaj   +1 more source

Acral Mesenchymal Spindle Cell Neoplasm With a Novel HMGA2::NCOA2 Fusion

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Molecular profiling has revolutionized the field of soft tissue pathology, enhancing diagnostic precision and treatment strategies. The integration of molecular analysis and immunohistochemistry has been crucial for classifying diagnostically challenging acral mesenchymal neoplasms.
Grace Z. Armstrong, Carina A. Dehner, Eitan Halper‐Stromberg, Esther Baranov, Anna C. Eden, Rachel P. Kowal   +5 more
wiley   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

European Journal of Dental Education, EarlyView.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer, Yusuf Balcı, Gaye Bölükbaşı, Betul İlhan, Pelin Güneri   +4 more
wiley   +1 more source

Malignant Progression in Two Children with Multiple Osteochondromas [PDF]

Sarcoma, 2010
Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clinical, radiographic, and histopathological factors.
Schmale, Gregory A., Hawkins, Douglas S., Rutledge, Joe, Conrad, Ernest U.   +3 more
openaire   +2 more sources

Successful repair of a carpal sheath synovial hernia using a polypropylene mesh

Equine Veterinary Education, EarlyView.
Summary A cob‐cross mare presented with a carpal sheath synovial hernia on the distolateral antebrachium following carpal sheath tenoscopy to treat a radial physeal exostosis and deep digital flexor tendon injury. The presumed source of pain was the weakened skin over the hernia as the intrathecal pathology identified at the initial tenoscopy had ...
S. R. L. Neild, J. D. Stack, M. D. Cullen, B. M. Curnow   +3 more
wiley   +1 more source

Physiotherapist's Management of Suspected Cauda Equina Syndrome in the United Kingdom: A National Survey

Physiotherapy Research International, Volume 31, Issue 2, April 2026.
ABSTRACT Background and Purpose Cauda Equina Syndrome (CES) is a rare but serious spinal condition requiring urgent diagnosis and management. Physiotherapists in UK musculoskeletal (MSK) services increasingly encounter suspected CES cases, but little is known about their clinical decision‐making and referral practices.
Rob Tyer, Nick Livadas, Robert Hogg
wiley   +1 more source

Osteochondroma of the scapula associated with a subclavian artery pseudoaneurysm: Case report

SAGE Open Medical Case Reports, 2019
Osteochondromas rarely induce vascular complications by mechanical compression. We present the case of a subclavian artery pseudoaneursym caused by an osteochondroma of the scapula in a 67-year-old male.
Ana Oljaca, Daniela Hirzberger, Marko Bergovec, Kurt Tiesenhausen, Stephan H Koter, Joerg Friesenbichler, Christian Viertler, Andreas Leithner   +7 more
doaj   +1 more source