Results 61 to 70 of about 1,671 (162)

Multiple Subungual Osteochondromas: A Case Report

Journal of the Korean Orthopaedic Association, 2004
The osteochondroma is a common benign bone tumor, which is only rarely observed in a subungal loca-tion, especially in the fingers. We present a case of multiple subungal osteochondromas, which occurred in the distal phalanges causing nail deformities and pain.
Goo Hyun Baek, Jin Sam Kim, Moon Sang Chung   +2 more
openaire   +1 more source

A Case of Trichorhinophalangeal Syndrome Caused by a Novel Heterozygous Nonsense Mutation in the TRPS1 Gene

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT A 17‐year‐old male patient with a c.2065C>T heterozygous nonsense mutation in the TRPS1 gene has sparse, soft hair; short thumbs and toes; misaligned teeth; and X‐ray findings of short distal thumb phalanges, depressed middle finger phalanges bases, and short toe proximal phalanges.
Cailing E., Maaz Ahmed, Yu Wang, Jing Wang, Shixing Wu, Zudong Meng   +5 more
wiley   +1 more source

Hereditary Multiple Osteochondromas and Acute Lymphoblastic Leukemia: A Possible Role for EXT1 and EXT2 in Hematopoietic Malignancies

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi, Carmela Fusco, Rosamaria Mura, Carla Cerruto, Leonardo D'Agruma, Salvatore Carnazzo, Marco Castori, Salvatore Savasta   +7 more
wiley   +1 more source

Arthroscopic Excision of the Intra‐articular Osteochondroma: A Technical Note

Arthroscopy Techniques, Volume 14, Issue 5, May 2025.
Abstract Osteochondromas are relatively common benign bone tumors that, when located intra‐articularly, can cause severe joint pain, mechanical symptoms, and functional limitation. Classically removed with an open approach, the development of a less‐invasive surgical technique for the removal of this lesion can aid in decreasing future morbidity for ...
Kristen N. Reikersdorfer, Connor Wright, Richard N. Puzzitiello, Serafina F. Zotter, Nikolaos K. Paschos   +4 more
wiley   +1 more source

Signaling systems affecting the severity of multiple osteochondromas

Bone, 2018
Multiple osteochondromas (MO) syndrome is a dominant autosomal bone disorder characterized by the formation of cartilage-capped bony outgrowths that develop at the juxtaposition of the growth plate of endochondral bones. MO has been linked to mutations in either EXT1 or EXT2, two glycosyltransferases required for the synthesis of heparan sulfate (HS ...
Virginia Piombo, Katja Jochmann, Daniel Hoffmann, Manuela Wuelling, Andrea Vortkamp   +4 more
openaire   +3 more sources

Outcomes and Management of Positive Margins in Chondrosarcoma With Soft Tissue Extension: A Case Series and Review of Literature

Cancer Reports, Volume 8, Issue 3, March 2025.
ABSTRACT Background Chondrosarcoma accounts for 20% of all bone sarcomas and may present with soft tissue extension. The presence of an extraosseous component, along with positive surgical margins, independently have been associated with increased risk of local recurrence and decreased survival.
Austin Yu, Trevor Poulson, Zachary Butler, Matthew Demetrious, Steven Gitelis, Alan T. Blank   +5 more
wiley   +1 more source

Multiple Intraarticular Osteochondromas of the Knee

Orthopedics and Rheumatology Open Access Journal, 2022
Osteochondroma is the most common benign growing bone tumor that usually affects the knee joint area. It often involves the long bone metaphysis, which occurs extraarticularly. Despite this, single intraarticular osteochondroma is rarely reported in the literature, but multiple knee osteochondromas is very rare and has not been reported so far.
openaire   +1 more source

A Case of Multiple Osteochondroma in the Rat.

Journal of Veterinary Medical Science, 1995
The occurrence of spontaneous osteochondroma in rats is extremely rare and only a few cases have been reported. Spontaneous multiple osteochondroma was found in a male SD strain rat, at the age of 58 weeks from the control group in a toxicity study. Histological findings of both a walnut-sized mass involving the humerus and scapula of right forelimb ...
H, Iwata, S, Yamamoto, S, Mikami, S, Yamakawa, Y, Hirouchi, K, Kobayashi, M, Enomoto   +6 more
openaire   +3 more sources

Spine Osteochondromas: are they always rare and harmless? A case series of six symptomatic cases

Coluna/Columna
Osteochondroma is the most common benign bone tumor, though spinal involvement is rare. This study presents a case series of six symptomatic spinal osteochondromas, including both solitary forms and cases associated with multiple hereditary exostoses ...
GABRIEL FARIAS ALVES, ALDERICO GIRãO CAMPOS DE BARROS, LUíS E. CARELLI   +2 more
doaj   +1 more source

Bone deformities with hereditary multiple osteochondromas

Danish Medical Journal
INTRODUCTION. Hereditary multiple osteochondromas (HMO) is a genetic skeletal disorder caused by defects in exostosin glycosyltransferase 1 (EXT1) or 2 (EXT2) genes. It develops mainly in the growth period and causes multiple osteochondromas (OC) in the physis of the long bones, leading to discomfort and deformities. This study aimed to investigate the
Brink Petersen, Rikke, Buch, Christina Damgaard, Færgemann, Christian, Nymark, Tine   +3 more
openaire   +3 more sources