Results 51 to 60 of about 6,048,088 (193)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Using Mentalizing and Psychopathy to Explore a Dimensional Model of Antisocial and Borderline Personality Disorder [PDF]

, 2014
Part one of the thesis reviews the literature on whether antisocial personality disorder (ASPD) and psychopathy represent distinct categories. This question was addressed by identifying studies with populations of individuals meeting criteria for ASPD ...
Carlisle, JR
core  

Relationship between personality traits and perinatal depression at Muhammadiyah Hospital Surabaya

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, 2023
Perinatal depression is a feeling disorder that occurs in a woman during pregnancy and after childbirth. Perinatal depression can be seen from various factors, one of which is personality traits.
Ninuk Dwi Ariningtyas, Putri Aqila, Era Catur Prasetya, Roni Subagyo   +3 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Dysfunctional beliefs and antisocial personality disorder

, 2008
Beck identified dysfunctional beliefs associated with personality disorders and these form the basis of the Personality Belief Questionnaire (PBQ). The PBQ has not yet been empirically examined in relation to antisocial personality disorder (ASPD); here,
Christopher, Gary, McMurran, Mary
core   +1 more source

Schema therapy for patients with Symptoms Obsessive–compulsive personality disorder (OCPD): A single case series study

مجله علوم روانشناختی, 2022
Background: Obsessive-compulsive personality disorder is characterized by a pervasive pattern of mental occupation with order, finalization and individual and interpersonal mental control.
Abas Bakhshipour, Majid Mahmoud Aliloo, samad fahimi   +2 more
doaj  

Exploring effectiveness of CBT in obese patients with binge eating disorder: personality functioning is associated with clinically significant change

BMC Psychiatry, 2023
Background Binge eating disorder (BED), as the most prevalent eating disorder, is strongly related to obesity and other somatic and psychiatric morbidity. Despite evidence-based treatments a considerable number of BED patients fail to recover.
Laura van Riel, Elske van den Berg, Marike Polak, Marjolein Geerts, Jaap Peen, Theo Ingenhoven, Jack Dekker   +6 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Detection of Significant Association Between Variants in Cannabinoid Receptor 1 Gene (CNR1) and Personality in African–American Population

Frontiers in Genetics, 2018
Background: Several studies have revealed significant associations between single nucleotide polymorphisms (SNPs) in the cannabinoid receptor 1 (CNR1) gene and a broad spectrum of psychiatric disorders such as major depressive disorder (MDD), attention ...
Yinghao Yao, Yi Xu, Junsheng Zhao, Yunlong Ma, Kunkai Su, Wenji Yuan, Jennie Z. Ma, Thomas J. Payne, Ming D. Li, Ming D. Li, Ming D. Li   +10 more
doaj   +1 more source