Results 61 to 70 of about 8,620,985 (191)

Recommendations for the use of cladribine tablets for the pathogenetic treatment of patients with highly active multiple sclerosis

Неврология, нейропсихиатрия, психосоматика, 2020
Currently, special attention is paid to timely treatment for active forms of multiple sclerosis (MS), especially for highly active MS (HAMS), in which there are ≥2 exacerbations and corresponding activity signs that are detected by magnetic resonance ...
K. Z. Bakhtiyarova, A. N. Boyko, Ya. V. Vlasov, Z. A. Goncharova, M. V. Davydovskaya, M. N. Zakharova, N. A. Malkova, A. I. Nilov, S. A. Sivertseva, N. N. Spirin, N. A. Totolyan, F. A. Khabirov, M. V. Shumilina   +12 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Case Report: Metachronous bilateral primary and secondary angiosarcoma of the breast

Frontiers in Oncology
BackgroundBreast angiosarcoma (AS) is an extremely rare and aggressive malignancy with no standardized treatment guidelines. We report an exceptional case of metachronous bilateral primary and secondary AS in a single patient, highlighting the diagnostic
Shulian Zhuang, Jianxing Zhang, Miao Chen, Yunsi Lai, Ling Chen   +4 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Classification rule for ten year MACE Risk in primary care tarragona older adults with type2 diabetes: a CHAID decision-tree analysis [PDF]

CHAID; Decision tree; Diabetes; MACECHAID; Árbol de decisión; Diabetes; MACECHAID; Decision tree; Diabetes; MACECardiovascular disease is the leading cause of mortality among individuals with Type 2 Diabetes Mellitus (T2DM). This study developed a simple
Vila-Corcoles, Angel, de diego cabanes, cinta, Ribas Seguí, Domingo J, Forcadell, Mª José, Ochoa-Gondar, Olga, SATUÉ-GRACIA, Eva, Martín Luján, Francisco M   +6 more
core   +1 more source

Current knowledge and future research directions in treatment-related second primary malignancies

EJC Supplements, 2014
Currently, 17–19% of all new primary malignancies occur in survivors of cancer, causing substantial morbidity and mortality. Research has shown that cancer treatments are important contributors to second malignant neoplasm (SMN) risk.
Lindsay M. Morton, Anthony J. Swerdlow, Michael Schaapveld, Safaa Ramadan, David C. Hodgson, John Radford, Flora E. van Leeuwen   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Evidence informed practice in Primary Education: an unintended but valuable resource

, 2009
This considers the potential of the Teacher Training Resource Bank (TTRB) as a resource for professional development with primary education. Although, the portal was designed with the needs of Teacher Education in mind, the resource has been evaluated as
Blamires, M., National Association of Primary Education   +1 more
core  

Urinary neopterin and nitric oxide metabolites as markers of interferon beta-1a activity in primary progressive multiple sclerosis

, 2010
Background: Interferon beta has not been demonstrated to be effective in exploratory phase 2 clinical trials in primary progressive multiple sclerosis.
SM Leary, Thompson, A.J., A. Petzold, Petzold, A.F.S., AJ Thompson, G. Giovannoni, Leary, S.M., Miller, D. H., K. Rejdak, DH Miller, Rejdak, K., Giovannoni, G.   +11 more
core   +1 more source