Results 231 to 240 of about 9,019,411 (282)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Multiple primary malignant tumors [PDF]

Ca-A Cancer Journal for Clinicians, 1964
Charles G Moertel
exaly   +3 more sources

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Multiple Primary Malignancies

JAMA, 1961
In the case here described, the patient had primary malignant lesions in 4 distinct organ-systems: adenocarcinoma of the duodenum, adenocarcinoma of the breast, adenocarcinoma of the endometrium, and multiple basal-cell carcinomata of the skin. The diagnoses were verified histologically.
S, WERTHAMER, M, JABUSH, J, SCHULMAN
openaire   +2 more sources

Multiple Primary Malignancies

Archives of Surgery, 1966
MULTIPLE primary malignancies were considered rare and unusual when first described by Billroth 1 in 1879. As subsequent authors have shown, 2,3 they are relatively common. The surgeon should be aware of their frequent sites and behavior. In order to delineate these important factors in relation to multiple malignancies, patients with multiple ...
B L, Bachulis, R D, Williams
openaire   +2 more sources

Multiple Primary Malignant Neoplasms

Journal of Urology, 1984
AbstractA 75‐year‐old man developed neurilemmoma of the left eighth cranial nerve, adenomatous polyp of the sigmoid colon, adenocarcinoma of the prostate, mixed cell type lymphoma of the right neck, and infiltrating ductal carcinoma of the right breast metachronously during a period of 38 years. The cancer of the right breast occurred 7 years after the
S S, Lee, B K, Wasiljew, K T, Song
openaire   +2 more sources

Multiple Primary Malignancy in the Elderly

Journal of the American Geriatrics Society, 1978
ABSTRACT: The longer a patient lives, the more predisposed he is to become host to primary malignant neoplasms at various sites. Hence the importance of follow‐up clinics in long‐term care facilities. Data on multiple malignancies at Oak Forest Hospital are presented.
D B, Rao, R R, Batina, M, Ray
openaire   +2 more sources

Multiple Primary Malignant Neoplasms

Archives of Surgery, 1969
Almost a century ago Billroth1described two patients in both of whom developed more than one primary malignant neoplasm. Although not published until 1869, one of these patients was reported in 1860 according to Warren and Gates2and Judge.3Since that time, there has been a permutation of the occurrence rate of this disease from that of a rare medical ...
L V, Campbell, A L, Watne
openaire   +2 more sources