Results 91 to 100 of about 940,352 (300)

Clinicopathologic Characteristics of Patients with Gastric Superficial Neoplasia and Risk Factors for Multiple Lesions after Endoscopic Submucosal Dissection in a Western Country

GE: Portuguese Journal of Gastroenterology, 2019
Background: Endoscopic submucosal dissection (ESD) is a treatment for early gastric neoplasms that preserves the stomach. However, the risk of multiple lesions persists.
Gisela Brito-Gonçalves, Diogo Libânio, Pedro Marcos, Inês Pita, Rui Castro, Inês Sá, Mário Dinis-Ribeiro, Pedro Pimentel-Nunes   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Identification of Methylated Genes Associated with Aggressive Clinicopathological Features in Mantle Cell Lymphoma

, 2011
Background: Mantle cell lymphoma (MCL) is genetically characterized by the t(11;14)(q13;q32) translocation and a high number of secondary chromosomal alterations. The contribution of DNA methylation to MCL lymphomagenesis is not well known.
Campo Elías, Fernandez, Veronica, Sílvia Beà, Magda Pinyol, Hernández Luis, Beà Bobet, Sílvia M., Fernàndez Verònica, Jares, Pedro, Anna Enjuanes, Andreas Rosenwald, Pinyol Magda, Verònica Fernàndez, Rosenwald, Andreas, Pinyol, Magda, Pedro Jares, German Ott, López-Guillermo Armando, Enjuanes Anna, Bea, Silvia, Hernández, Luis, López Guillermo, Armando, Beà Sílvia, Rosenwald Andreas, Fernàndez Pascual, Verònica, Armando López-Guillermo, Navarro, Alba, Jares Pedro, Lopez-Guillermo, Armando, Ott, German, Jares Gerboles, Pedro, Luis Hernández, Campo Güerri, Elias, Navarro Alba, Elías Campo, Campo, Elias, Alba Navarro, Enjuanes, Anna, Ott German   +37 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

INCIDENCE OF MULTIPLE PRIMARY MALIGNANT NEOPLASMS IN SIBERIA AND THE FAR EAST

Паёми Сино
Objective: To investigate the occurrence of multiple primary malignant neoplasms (MPMNs) in Siberia and the Far East from 2011 to 2022. Methods: The calculation and analysis of MPMN incidence were based on data collected from the Federal Statistical ...
Zhuykova Liliya Dmitrievna, Pikalova Lidiya Valentinovna, Zavyalova Marina Viktorovna, Choynzonov Evgeniy Lkhamawyrenovich, Kononova Galina Aleksandrovna, Zavyalov Aleksandr Vasilievich   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Multiple primary malignant neoplasms: Data of Cumhuriyet University

, 2012
Amaç. Onkolojik tedavilerdeki gelişmeler ve beklenen yaşam süresinin uzaması, tedavilerin geç yan etkileri ve ikinci kanserlerin gelişimi gibi sorunları da beraberinde getirmiştir.
Ebru Akkaş Atasever, Saadettin Kılıçkap, Turgut Kaçan, Şafak Şahin, Nalan Babacan Akgül, Mehmet Fuat Eren, Birsen Yücel, Yıllar Okur   +7 more
core  

Central Airway Carcinoid Tumorlets Following Resection of a Typical Carcinoid Tumor

Diagnostics
Pulmonary neuroendocrine proliferations and neoplasms represent a broad spectrum of diseases, ranging from neuroendocrine cell hyperplasia and tumorlets to carcinoid tumors.
Kyungsoo Bae, Kyung Nyeo Jeon, I Re Heo, Hyo Jung An, Dae Hyun Song   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A case of primary malignant neoplasms associated with penile cancer and prostatic cancer [PDF]

, 1986
A case of a 79-year-old man with penile cancer and prostate cancer is reported. The pathological study of surgical specimens disclosed well-differentiated squamous cell carcinoma of the penis and poorly differentiated adenocarcinoma of the prostate. This
保母, 光俊, 冨田, 雅乃, 岡田, 耕市, 沼, 秀親   +3 more
core