The roles and applications of extracellular vesicles in cancer
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
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Primary ovarian neuroendocrine neoplasia with concurrent large epithelial borderline ovarian tumor, coexistent with non-malignant pleural effusion and multiple uterine fibroids: a case report and review of the literature. [PDF]
Mohsin M+4 more
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Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim+8 more
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Synchronous Primary Malignancies: Incidental Detection of Ascending Colon Adenocarcinoma During Staging of Invasive Ductal Carcinoma of the Breast. [PDF]
Balde S+10 more
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Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka+10 more
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A Rare Case of Triple Primary Malignant Neoplasms (RCC and Colon Cancer) Detected by 18F-FDG PET/CT. [PDF]
Nikolova P+6 more
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Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu+15 more
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Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
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Plasma Cell-Rich Lymphoid Neoplasm in an Endocervical Polyp of the Uterine Cervix in a Perimenopausal 52-Year-Old Woman. [PDF]
Patel A, Haas J, Kueck A.
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