Results 51 to 60 of about 3,934,112 (267)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Formation Of Green Buying Strategy On The Scope Of Consumer Decision Making Behavior

Online Academic Journal of Information Technology, 2013
As the natural resources are becoming scarce and the concept of environmentalism is on the rise, green buying behavior has increased the attention of many academicians and practitioners as an emerging strategy.
M. Yaman Oztek, Ozgur Cengel
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Random Projections For Large-Scale Regression

, 2017
Fitting linear regression models can be computationally very expensive in large-scale data analysis tasks if the sample size and the number of variables are very large.
B. McWilliams, D. Achlioptas, M.W. Mahoney, O.-A. Maillard, P. Dhillon, P.S. Dhillon, R.D. Cook, S. Dasgupta, T. Marzetta   +8 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Multiple-time correlation functions for non-Markovian interaction: Beyond the Quantum Regression Theorem

, 2004
Multiple time correlation functions are found in the dynamical description of different phenomena. They encode and describe the fluctuations of the dynamical variables of a system.
A. G. Redfield, A. G. Redfield, C. Gardiner, Daniel Alonso, G. Lindblad, G. C. Hegerfeldt, H. J. Carmichael, H. J. Carmichael, Inés de Vega, J. Dalibard, J. D. Cresser, N. Gisin, N. G. van Kampen   +12 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Sensitivity Analysis of an OLS Multiple Regression Inference with Respect to Possible Linear Endogeneity in the Explanatory Variables, for Both Modest and for Extremely Large Samples

Econometrics, 2020
This work describes a versatile and readily-deployable sensitivity analysis of an ordinary least squares (OLS) inference with respect to possible endogeneity in the explanatory variables of the usual k-variate linear multiple regression model.
Richard A. Ashley, Christopher F. Parmeter   +1 more
doaj   +1 more source

Pengaruh Kualitas Produk, Store Atmosphere, Dan Lokasi Terhadap Keputusan Pembelian Untuk Produk Fashion Pada Distro Di Kota Palembang [PDF]

, 2016
This study was conducted to determine the effect of product quality, store atmosphere, and the location of the purchasing decision for fashion products in the city of Palembang. This type of research is done by using a field study / survey.
Putri, Melinda
core