Results 81 to 90 of about 3,934,112 (267)
Market Analysis of Smallholder Goat Enterprise under Tropical Conditions
Agricultura Tropica et Subtropica, 2017 Though smallholder goat enterprise has been a major source of livelihood in most African communities for ages, yet little efforts exist to explore its full potential through commercialization.
Yesufu Olufemi Adedotun +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Prediction of the Main Engine Power of a New Container Ship at the Preliminary Design Stage
Management Systems in Production Engineering, 2017 The paper presents mathematical relationships that allow us to forecast the estimated main engine power of new container ships, based on data concerning vessels built in 2005-2015.
Cepowski Tomasz
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Estimation of the Hazardous Chemical Leakage Scale Inside Buildings Using CFD
BuildingsIncreased industrialization and aging infrastructure have resulted in leaks of hazardous chemicals, such as CO. Leak modeling is crucial to developing emergency response strategies. Therefore, we simulated the time to criticality (TTC), which is the time
Kisung Kim, Dongwoo Song
doaj +1 more source
Estimators of the multiple correlation coefficient: local robustness and confidence intervals. [PDF]
Many robust regression estimators are defined by minimizing a measure of spread of the residuals. An accompanying R-2-measure, or multiple correlation coefficient, is then easily obtained.
Croux, Christophe, Dehon, C
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source