Results 151 to 160 of about 669,844 (267)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Orthodontic Root Resorption in Spontaneously Hypertensive Rats: Modulation by β2-Adrenergic Receptor Blockade. [PDF]

J Clin Med
Yoshida T, Sato T, Takahashi M, Ichikawa S, Tabuchi M, Miyazawa K.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Underground Signals: The Ecological Power of Root Volatiles. [PDF]

Adv Sci (Weinh)
Cao X, Song N, Verheggen F, Pérez-Hedo M, Clavijo McCormick A, Cusumano A, de Fouchier A, Wang B, Wang CZ, Jacquin-Joly E, Felton GW, Gurr GM, Guo H, Li J, Zhang J, Chen L, Wang M, Ricupero M, Han P, He P, Yan Q, Tang Q, Liu Q, An S, Kong X, Sun X, Ren X, Song Y, Liu Y, Guo Y, Li Y, Sun X.   +31 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Multimodal Analytical Platform Coupled With Biological Assays Unravels Tissue-Specific Chemical Profiles, Spatial Metabolite Distributions and Bioactivities of Root Xylem and Root Bark of <i>Tripterygium wilfordii</i>. [PDF]

Anal Sci Adv
Zhang ZM, Xu KL, Zhang Q, Lin YQ, Wei F, Dan Wang Y.   +5 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Dynamic Assembly and Multifunctional Roles of Plant Endophytic Microbiomes. [PDF]

Microorganisms
Song J, Liu W, Sun Y, Shi J, Liu M, Dai Y, Zuo Y, Yao Q.   +7 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Regulatory effects of mepiquat chloride on soybean yield formation and physiological responses to drought stress. [PDF]

Front Plant Sci
Zhou X, Li X, Zhao W, Wang X, Ma Y, Dong S.   +5 more
europepmc   +1 more source