Results 151 to 160 of about 15,981,515 (305)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Spatial Collinearity Constrains Multivariate Molecular-Enriched Network Estimation. [PDF]

Hum Brain Mapp
Lawn T, Nakuci J, Williams SCR, Turkheimer F, Mehta MA.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Seeing Skin Tone Differently: An Experimental Comparison of Objective Measurements and Subjective Perceptions. [PDF]

Bioengineering (Basel)
Sooriyaarachchi J, Proulx C, Pecora L, Rivest-Hénault D, Vaughan T, Rainville MA, Saull A, Fortin A, Jiang D.   +8 more
europepmc   +1 more source

An inequality decomposition method which minimizes equivalence scales contamination problems. [PDF]

Decomposable measures are a useful tool to analyze the impact of households characteristics on income or expenditure inequality. However, the results are sensitive to the choice of equivalence scales in a heterogenous population. In this paper, we assume
Río, Coral del, Ruiz-Castillo, Javier
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Most significant changes in the Coello River Basin

, 2012
SCALES
core   +1 more source

Weighted multi-scale and wavelet-enhanced Segment Anything Model for salient object detection. [PDF]

PLoS One
Liu Z, Tian D.
europepmc   +1 more source

Solution of a Quadratic Nonlinear Problem with Multiple Scales Lindstedt-Poincare Method

A recently developed perturbation algorithm namely the Multiple Scales Lindstedt-Poincare method (MSLP) is employed to solve an equation with quadratic nonlinearity.
Pakdemirli, M, Sari, G
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source