Results 81 to 90 of about 7,321,143 (344)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Stratification of Heterogeneity in the Lithosphere of Mars From Envelope Modeling of Event S1222a and Near Impacts: Interpretation and Implications for Very‐High‐Frequency Events

Geophysical Research Letters, 2023
We have modeled the high‐frequency seismogram envelopes of the large event S1222a and four recently identified near impacts recorded by the InSight mission by introducing a stratification of velocity and attenuation into a multiple‐scattering approach ...
S. Menina, L. Margerin, T. Kawamura, G. Heller, M. Drilleau, Z. Xu, M. Calvet, R. F. Garcia, B. Knapmeyer‐Endrun, S. Carrasco, K. Onodera, P. Lognonné, A. Stott, W. B. Banerdt   +13 more
doaj   +1 more source

Sonic Gradient Index Lens for Aqueous Applications

, 2010
We study the acoustic scattering properties of a phononic crystal designed to behave as a gradient index lens in water, both experimentally and theoretically.
Cai, Liang-Wu, Martin, Theodore P., Nicholas, Michael, Orris, Gregory J., Sanchez-Dehesa, Jose, Torrent, Daniel   +5 more
core   +1 more source

Random projections through multiple optical scattering: Approximating Kernels at the speed of light [PDF]

IEEE International Conference on Acoustics, Speech, and Signal Processing, 2015
Random projections have proven extremely useful in many signal processing and machine learning applications. However, they often require either to store a very large random matrix, or to use a different, structured matrix to reduce the computational and ...
Alaa Saade, F. Caltagirone, I. Carron, L. Daudet, Angélique Drémeau, S. Gigan, Florent Krzakala   +6 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Polarized Radiative Transfer Simulations: A Tutorial Review and Upgrades of the Vector Discrete Ordinate Radiative Transfer Computational Tool

Frontiers in Remote Sensing, 2022
We present an overview and several important upgrades to the Vector Discrete Ordinate Radiative Transfer (VDISORT) code. VDISORT is a polarized (vector) radiative transfer code that can be applied to a wide range of research problems including the Earth ...
Zhenyi Lin, Snorre Stamnes, Wei Li, Yongxiang Hu, Istvan Laszlo, Si-Chee Tsay, Alexander Berk, Jeannette van den Bosch, Knut Stamnes   +8 more
doaj   +1 more source

Multiple-Scattering Series For Color Transparency

, 1992
Color transparency CT depends on the formation of a wavepacket of small spatial extent. It is useful to interpret experimental searches for CT with a multiple scattering scattering series based on wavepacket-nucleon scattering instead of the standard one
A. H. Mueller, A. H. Mueller, A. S. Carroll, B. K. Jennings, B. K. Jennings, B. K. Jennings, B. K. Jennings, B. Pire, B. Z. Kopeliovich, B. Z. Kopeliovich, B. Z. Kopeliovich, F. E. Low, G. A. Miller, G. A. Miller, G. A. Miller, G. R. Farrar, H-n Li, J. Botts, J. Botts, J. Botts, J. Botts, J. Botts, J. Gunion, J. P. Ralston, J. P. Ralston, L. Frankfurt, L. Frankfurt, L. Frankfurt, L. Frankurt, N. N. Nikolaev, S. Heppelmann, S. J. Brodsky, S. J. Brodsky, S. Nussinov, W. R. Greenberg   +34 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Multiple Coulomb Scattering in Thin Silicon

, 2014
We present a measurement of multiple Coulomb scattering of 1 to 6 GeV/c electrons in thin (50-140 um) silicon targets. The data were obtained with the EUDET telescope Aconite at DESY and are compared to parametrisations as used in the Geant4 software ...
Berger, Niklaus, Buniatyan, Armen, Eckert, Patrick, Förster, Fabian, Gredig, Roman, Kiehn, Moritz, Kovalenko, Oxana, Philipp, Raphael, Schöning, André, Wiedner, Dirk   +9 more
core   +1 more source

Imaging depth and multiple scattering in laser speckle contrast imaging

Journal of Biomedical Optics, 2014
. Laser speckle contrast imaging (LSCI) is a powerful and simple method for full field imaging of blood flow. However, the depth dependence and the degree of multiple scattering have not been thoroughly investigated.
Mitchell A. Davis, S. S. Kazmi, Andrew K. Dunn   +2 more
semanticscholar   +1 more source