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Pediatric multiple sclerosis (MS) represents a particular MS subgroup with unique diagnostic challenges and many unanswered questions. Due to the narrow window of environmental exposures and clinical disease expression, children with MS may represent a particularly important group to study to gain a better understanding of MS pathogenesis.
Vikram Bhise+2 more
openaire +4 more sources
Cytokine, Chemokine, and Neurofilament Light Chain Signatures in LGI1 Autoimmune Encephalitis
ABSTRACT Objectives To investigate the value of cytokine, chemokine, and neurofilament light chain (NfL) concentrations in predicting relapse risk, chronic epilepsy, and functional impairment in LGI1 autoimmune encephalitis (AE). Methods Cytokines/chemokines (IL‐1‐beta, IL‐2, IL‐4, IL‐5, IL‐6, IL‐8/CXCL8, IL‐10, IL‐12p70, IL‐13, IL‐17A, GM‐CSF, TNF ...
Albert Aboseif+17 more
wiley +1 more source
MULTIPLE SCLEROSIS: THE LOCATION OF LESIONS WITH RESPECT TO SYMPTOMS [PDF]
E. W. Taylor
openalex +1 more source
Real World Effectiveness and Tolerability of Novel Monoclonal Antibodies and Rituximab for NMOSD
ABSTRACT In this multicenter retrospective cohort study of 135 people with aquaporin‐4 IgG+ neuromyelitis optica spectrum disorder (NMOSD), some of whom were exposed to multiple therapies, we evaluated the effectiveness and tolerability of rituximab (n = 111) and novel monoclonal antibodies (nMAbs): eculizumab (n = 9), inebilizumab (n = 23), and ...
Zarmina Javed+9 more
wiley +1 more source
MULTIPLE SCLEROSIS, WITH A REPORT OF TWO ADDITIONAL CASES, WITH NECROPSY [PDF]
WILLIAM G. SPILLER, C D Camp
openalex +1 more source
Genetics of multiple sclerosis
A genetic contribution to the pathogenesis of MS has been proven by discovery of HLA-DR2 locus over 40 years ago and description of familial aggregation of MS. Novel array technologies in parallel with analytical tools, improved central sample collection in MS centres and intensified international collaborations have led to the identification of a ...
Rogier Q. Hintzen, I A Hoppenbrouwers
openaire +5 more sources
ABSTRACT Objective Neurodegeneration with brain iron accumulation (NBIA) comprises rare genetic disorders characterized by predominantly extrapyramidal symptoms and iron deposition in the basal ganglia. Conventional magnetic resonance imaging (MRI) detects qualitative changes but cannot accurately quantify iron accumulation. Quantitative susceptibility
Özge Uygun+19 more
wiley +1 more source
ADDITIONAL CONTRIBUTION TO CASES OF MULTIPLE SCLEROSIS WITH AUTOPSIES [PDF]
S. G. Webber
openalex +1 more source
Biochemical Studies on Sera or Cerebrospinal Fluids of Neurologically Normal Persons and Patients with Multiple Sclerosis [PDF]
Ervin Kovács, J. Kovács
openalex +3 more sources
OBJECTIVE: To study the epidemiology of multiple sclerosis in Hong Kong Chinese. DESIGN: Cross-sectional questionnaire survey. SETTING: Neurology and paediatric neurology departments in Hong Kong from January through June 1999.
Chan, YW+5 more
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