Results 151 to 160 of about 6,495,609 (392)

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Premorbid cognitive leisure independently contributes to cognitive reserve in multiple sclerosis [PDF]

, 2010
James Sumowski, Glenn R. Wylie, Angela Gonnella, Nancy D. Chiaravalloti, John DeLuca   +4 more
openalex   +1 more source

A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis

, 2023
Lynn Daboul, Carly M. O’Donnell, Moein Amin, Paulo Rodrigues, J. Andrew Derbyshire, Christina Azevedo, Amit Bar‐Or, Eduardo Caverzasi, Peter A. Calabresi, Bruce Cree, Léorah Freeman, Roland G. Henry, Erin E. Longbrake, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Vesna Prchkovska, Praneeta Raza, Marc Ramos, Rohini Samudralwar, Matthew K. Schindler, Elias S. Sotirchos, Nancy L. Sicotte, Andrew Solomon, Russell T. Shinohara, Daniel S. Reich, Pascal Sati, Daniel Ontaneda   +27 more
openalex   +2 more sources

Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

Annals of Neurology, 2017
Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations.
G. Disanto, Christian Barro, P. Benkert, Y. Naegelin, Sabine Schädelin, Antonella Giardiello, C. Zecca, K. Blennow, H. Zetterberg, D. Leppert, L. Kappos, C. Gobbi, J. Kuhle, J. Kuhle, Johannes Lorscheider, Ö. Yaldizli, T. Derfuss, L. Kappos, G. Disanto, C. Zecca, C. Gobbi, P. Benkert, L. Achtnichts, K. Nedeltchev, C. Kamm, A. Salmen, A. Chan, P. Lalive, C. Pot, M. Schluep, C. Granziera, R. D. Du Pasquier, S. Müller, Jochen Vehoff   +33 more
semanticscholar   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study [PDF]

, 2019
Marloes Hagens, Sandeep S.V. Golla, Bieneke Janssen, Daniëlle J. Vugts, Wissam Beaino, Albert D. Windhorst, James O’Brien-Brown, Michael Kassiou, Robert C. Schuit, Lothar A. Schwarte, Helga E. de Vries, Joep Killestein, Frederik Barkhof, Bart N.M. van Berckel, Adriaan A. Lammertsma   +14 more
openalex   +1 more source

Retinal Hyperreflecting Foci Associate With Cortical Pathology in Multiple Sclerosis [PDF]

, 2022
Marta Pengo, Silvia Miante, Silvia Franciotta, Marta Ponzano, Tommaso Torresin, Francesca Bovis, Francesca Rinaldi, Paola Perini, Martina Saiani, Monica Margoni, Alessandra Bertoldo, Maria Pia Sormani, Elisabetta Pilotto, Edoardo Midena, Paolo Gallo, Marco Puthenparampil   +15 more
openalex   +1 more source

The Case of a 28‐Year‐Old Woman With Medically Refractory Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present the case of a 28‐year‐old right‐handed woman with medically refractory focal epilepsy. Her seizure semiology and electroencephalography (EEG) indicated a seizure onset zone in the right central‐parietal area. However, both MRI and PET scans were unremarkable, showing no focal lesions or areas of altered metabolism.
Rishi Sharma, Ilo Leppik, Thomas Henry, Thaddeus Walczak, Sima Patel, Robert McGovern   +5 more
wiley   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis

Nature Communications
Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1 ...
Mark Walkenhorst, Jana K. Sonner, Nina Meurs, Jan Broder Engler, Simone Bauer, Ingo Winschel, Marcel S. Woo, Lukas Raich, Iris Winkler, Vanessa Vieira, Lisa Unger, Gabriela Salinas, Olivier Lantz, Manuel A. Friese, Anne Willing   +14 more
doaj   +1 more source