Results 221 to 230 of about 6,039,132 (349)

OPTIC NERVE INVOLVEMENT AND DIPLOPIA AS INITIAL MANIFESTATIONS OF MULTIPLE SCLEROSIS

, 1968
Uri Leibowitz, Milton Alter
openalex   +1 more source

Multiple Sclerosis [PDF]

, 1960
H. Miller, A Ridley, Kurt Schapira
openalex   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Frequency of multiple sclerosis in three Australian cities--Perth, Newcastle, and Hobart. [PDF]

, 1968
M. G. McCall, T. Le G. Brereton, Alice Dawson, Keith S. Millingen, J. M. Sutherland, E.D. Acheson   +5 more
openalex   +1 more source

A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.

New England Journal of Medicine, 2006
C. Polman, P. W. O'connor, E. Havrdová, M. Hutchinson, L. Kappos, David H. Miller, J. Phillips, F. Lublin, G. Giovannoni, A. Wajgt, M. Toal, F. Lynn, M. Panzara, A. Sandrock   +13 more
semanticscholar   +1 more source

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

Erratum: Developing a minimally invasive gene therapy for multiple sclerosis. [PDF]

Mol Ther Methods Clin Dev
Nijhuis PJH, Romijn M, Honing R, van Zon G, Huitinga I, de Winter F, Verhaagen J.   +6 more
europepmc   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

ATTEMPTS TO ISOLATE VIRUS FROM THE CEREBROSPINAL FLUID OF PATIENTS WITH MULTIPLE SCLEROSIS

, 1963
Halldór Thormar, Herdis von Magnus
openalex   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source