Results 231 to 240 of about 6,039,132 (349)
Clinically Relevant Patterns of Co-Fluctuating Structure and Function in Multiple Sclerosis. [PDF]
Eur J NeurolZhang J, Battaglini M, Cortese R, Stromillo ML, Mortilla M, Luchetti L, Gentile G, Portaccio E, Amato MP, Schoonheim MM, De Stefano N. +10 moreeuropepmc +1 more sourceVariations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes
Advanced Science, EarlyView.This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff +17 morewiley +1 more sourceChronically Stable, High‐Resolution Micro‐Electrocorticographic Brain‐Computer Interfaces for Real‐Time Motor Decoding
Advanced Science, EarlyView.A high‐resolution micro‐electrocorticographic (µECoG) brain‐computer interface (BCI) for real‐time motor decoding is reported. The application of flexible, scalable µECoG electrode arrays overcomes the insufficient spatial resolution in conventional ECoG BCIs.Erda Zhou, Xiner Wang, Jizhi Liang, Yang Liu, Qinrong Yang, Xingchen Ran, Lei Xia, Xiang Zou, Changjiang Liu, Liuyang Sun, Lei Peng, Liang Chen, Ying Mao, Zehan Wu, Tiger H. Tao, Zhitao Zhou +15 morewiley +1 more sourceNamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA
Advanced Science, EarlyView.MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...Lu Chen, Ying Liang, Hongyan Wei, Mengxing Liu, Jin Wu, Wei Li, Wenxuan Li, Yuxiao Jin, Yinshan Li, Wei Zhao, Min Xiao, Kaicheng Zhou, Shuai Yang, Wenqiang Yu +13 morewiley +1 more sourceGenetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature, 2011 S. Sawcer, G. Hellenthal, M. Pirinen, C. Spencer, N. Patsopoulos, L. Moutsianas, A. Dilthey, Z. Su, C. Freeman, S. Hunt, S. Edkins, Emma V. Gray, D. Booth, Simon C. Potter, A. Goris, G. Band, A. Oturai, A. Strange, J. Saarela, C. Bellenguez, B. Fontaine, M. Gillman, B. Hemmer, R. Gwilliam, F. Zipp, Alagurevathi Jayakumar, Roland Martin, S. Leslie, S. Hawkins, E. Giannoulatou, S. D'alfonso, H. Blackburn, F. Martinelli Boneschi, J. Liddle, H. Harbo, M. L. Pérez, A. Spurkland, M. Waller, M. Mycko, M. Ricketts, M. Comabella, Naomi Hammond, I. Kockum, O. T. McCann, M. Ban, P. Whittaker, A. Kemppinen, P. Weston, C. Hawkins, S. Widaa, J. Zajicek, S. Dronov, N. Robertson, S. Bumpstead, L. Barcellos, R. Ravindrarajah, R. Abraham, L. Alfredsson, K. Ardlie, C. Aubin, A. Baker, K. Baker, S. Baranzini, L. Bergamaschi, R. Bergamaschi, A. Bernstein, A. Berthele, M. Boggild, J. Bradfield, D. Brassat, S. Broadley, D. Buck, H. Butzkueven, R. Capra, W. Carroll, P. Cavalla, E. Celius, S. Cepok, R. Chiavacci, F. Clerget-Darpoux, Katleen Clysters, G. Comi, M. Cossburn, I. Cournu-Rebeix, Mathew B. Cox, W. Cozen, B. Cree, A. Cross, D. Cusi, M. Daly, Emma Davis, P. D. de Bakker, M. Debouverie, M. D'hooghe, K. Dixon, R. Dobosi, B. Dubois, D. Ellinghaus, I. Elovaara, F. Esposito, Claire Fontenille, S. Foote, A. Franke, D. Galimberti, A. Ghezzi, J. Glessner, R. Gomez, O. Gout, C. Graham, S. Grant, F. Guerini, H. Hakonarson, P. Hall, A. Hamsten, H. Hartung, R. Heard, S. Heath, J. Hobart, M. Hoshi, C. Infante-Duarte, G. Ingram, Wendy M Ingram, T. Islam, M. Jagodic, M. Kabesch, A. Kermode, T. Kilpatrick, Cecilia Kim, N. Klopp, K. Koivisto, M. Larsson, M. Lathrop, J. Lechner-Scott, M. Leone, V. Leppä, U. Liljedahl, I. Bomfim, R. Lincoln, J. Link, Jianjun Liu, Å. Lorentzen, Sara Lupoli, F. Macciardi, T. Mack, M. Marriott, V. Martinelli, D. Mason, J. McCauley, F. Mentch, Inger‐Lise Mero, T. Mihalova, X. Montalban, J. Mottershead, K. Myhr, P. Naldi, W. Ollier, Alison Page, A. Palotie, J. Pelletier, L. Piccio, T. Pickersgill, F. Piehl, Susan Pobywajlo, H. Quach, P. Ramsay, M. Reunanen, R. Reynolds, J. Rioux, M. Rodegher, S. Roesner, J. Rubio, I. Rückert, M. Salvetti, E. Salvi, A. Santaniello, C. Schaefer, S. Schreiber, C. Schulze, R. Scott, F. Sellebjerg, K. Selmaj, D. Sexton, L. Shen, Brigid Simms-Acuna, S. Skidmore, P. Sleiman, C. Smestad, P. Sørensen, H. Søndergaard, J. Stankovich, R. Strange, A. Sulonen, E. Sundqvist, A. Syvänen, F. Taddeo, B. Taylor, J. Blackwell, P. Tienari, E. Bramon, A. Tourbah, M. Brown, E. Tronczyńska, J. Casas, N. Tubridy, A. Corvin, J. Vickery, Janusz Jankowski, P. Villoslada, H. Markus, Kai Wang, C. Mathew, J. Wason, C. Palmer, H. Wichmann, R. Plomin, E. Willoughby, A. Rautanen, J. Winkelmann, M. Wittig, R. Trembath, J. Yaouanq, A. Viswanathan, Haitao Zhang, N. Wood, R. Zuvich, P. Deloukas, C. Langford, A. Duncanson, J. Oksenberg, M. Pericak-Vance, J. Haines, T. Olsson, J. Hillert, A. Ivinson, P. D. De Jager, L. Peltonen, G. Stewart, D. Hafler, S. Hauser, G. McVean, P. Donnelly, Alastair Compston +241 moresemanticscholar +1 more sourceRedox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation
Advanced Science, EarlyView.Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu +5 morewiley +1 more sourceDnmt1 Alleviates S1PR1‐Mediated Pyroptosis after Spinal Cord Injury through Regulating Pon3 Expression
Advanced Science, EarlyView.This study systematically explores the action mechanism of Pon3 and its regulatory targets in spinal cord injury (SCI). It demonstrates that Dnmt1 regulates Pon3 expression by modulating methylation levels, thereby inhibiting S1PR1‐mediated pyroptosis and improving SCI prognosis.Birong Peng, Haolong Lin, Mi Zhang, Wenhao Kuang, Jiaqi Zhang, Shuai Wang, Yuanfang Sun, Wenning Xu, Lixin Zhu +8 morewiley +1 more source
