Results 241 to 250 of about 6,495,609 (392)

MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis

Jihane Frikeche, Marion David, Xavier Mouska, Damien Treguer, Yue Cui, Sandrine Rouquier, Enora Lecorgne, Emma Proïcs, Papa Babacar Fall, Audrey Lafon, Gregory Lara, Alexandra Menardi, David Fenard, Tobias Abel, Julie Gertner-Dardenne, Maurus de la Rosa, Céline Dumont   +16 more
openalex   +1 more source

Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis [PDF]

, 2017
Stefanie Hahn, George Trendelenburg, Madeleine Scharf, Yvonne Denno, S. Brakopp, Bianca Teegen, Christian Probst, Klaus‐Peter Wandinger, Mathias Buttmann, Axel Haarmann, Fruzsina Szabados, Mark V. Dahl, Tania Kümpfel, Peter Eichhorn, H. Gold, Friedemann Paul, Sven Jarius, Nico Melzer, W. Stöcker, Lars Komorowski   +19 more
openalex   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Clinical and electrophysiological study of polyneuropathy in patients with multiple sclerosis. [PDF]

Sci Rep
Flintere-Flinte A, Urbanovics D, Mironovs S, Berzina S, Kalnina J, Kenina E, Zolovs M, Kenina V.   +7 more
europepmc   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Nutrition and Lifestyle Behaviours for the Prevention and Management of Multiple Sclerosis. [PDF]

Nutrients
Titcomb TJ, Probst Y.
europepmc   +1 more source

Novel computer-based testing shows multi-domain cognitive dysfunction in patients with multiple sclerosis [PDF]

, 2018
Andrew D. Smith, Charles J. Duffy, Andrew Goodman   +2 more
openalex   +1 more source

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis

Multiple Sclerosis, 2018
X. Montalban, R. Gold, A. Thompson, Susana Otero-Romero, M. Amato, Dhia Chandraratna, M. Clanet, G. Comi, T. Derfuss, F. Fazekas, H. Hartung, E. Havrdová, B. Hemmer, L. Kappos, R. Liblau, C. Lubetzki, Elena Marcus, David H. Miller, T. Olsson, S. Pilling, K. Selmaj, A. Siva, P. Sørensen, M. Sormani, C. Thalheim, H. Wiendl, F. Zipp   +26 more
semanticscholar   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Gray Matter Hypoxia in the Brain of the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

, 2016
Tom Johnson, Ying Wu, Nabeela Nathoo, James A. Rogers, V. Wee Yong, Jeff F. Dunn   +5 more
openalex   +2 more sources