Results 261 to 270 of about 6,020,192 (375)

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

Therapeutic Advances in Pediatric Multiple Sclerosis. [PDF]

Children (Basel)
Walsh R, Chitnis T.
europepmc   +1 more source

ON THE FINE STRUCTURE OF THE DISTRIBUTION OF MULTIPLE SCLEROSIS

, 1967
John F. Kurtzke
openalex   +1 more source

Multiple Sclerosis (Prognosis and Treatment) [PDF]

, 1962
Allan A. Bailey
openalex   +1 more source

Neuropathological Evidence of Reduced Amyloid Beta and Neurofibrillary Tangles in Multiple Sclerosis Cortex

Annals of Neurology, EarlyView.
Multiple sclerosis (MS) and Alzheimer's disease are neurodegenerative diseases with age‐related disability accumulation. In MS, inflammation spans decades, whereas AD is characterized by Aβ plaques and neurofibrillary tangles (NFT). Few studies explore accumulation of amyloids in MS.
J. Pansieri, M. Pisa, S. Yee, A. Gutnikova, E. Ridgeon, R. Hickman, J.I. Spencer, M.M. Esiri, G.C. DeLuca   +8 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Hypoxic Neuroinflammation in the Pathogenesis of Multiple Sclerosis. [PDF]

Brain Sci
Hollingworth BYA, Pallier PN, Jenkins SI, Chen R.   +3 more
europepmc   +1 more source

Smoking and Multiple Sclerosis [PDF]

, 1964

openalex   +1 more source

UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia

Annals of Neurology, EarlyView.
UNC13A (rs12608932‐CC) is associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and shortens survival in ALS. We aim to describe the association for UNC13A and survival in FTD. We included 626 patients with FTD from Dutch memory clinics, including a subcohort of 150 patients with TDP‐43 pathology. Survival analyses
Lianne M. Reus, Sean W. Willemse, Sterre C.M. de Boer, Julie De Houwer, Willem L. Hartog, Merel O. Mol, Jeroen G. J. van Rooij, Niccolo Tesi, Laura Donker Kaat, Marc Hulsman, Everard G. B. Vijverberg, Henne Holstege, Wouter van Rheenen, Jan H. Veldink, Leonard H. van den Berg, John C. van Swieten, H. Seelaar, Sven J. van der Lee, Michael A. van Es, Yolande A. L. Pijnenburg   +19 more
wiley   +1 more source

Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription Factor STAT4

Angewandte Chemie, EarlyView.
The transcription factor STAT4 is a therapeutic target for autoimmune diseases. Here, para‐biaryl phosphates and phosphonates are presented as the first small‐molecule inhibitors of STAT4. The phosphonate Stafori‐1 selectively stabilizes STAT4 against thermal denaturation in cell lysates, and its cell‐permeable prodrug Pomstafori‐1 selectively inhibits
Nadiya Brovchenko, Angela Berg, Sabine Schubert, Julian Gräb, Theresa Münzel, Christoph Protzel, Kalaiselvi Natarajan, Thorsten Berg   +7 more
wiley   +2 more sources