Results 281 to 290 of about 6,495,609 (392)
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature, 2011 S. Sawcer, G. Hellenthal, M. Pirinen, C. Spencer, N. Patsopoulos, L. Moutsianas, A. Dilthey, Z. Su, C. Freeman, S. Hunt, S. Edkins, Emma V. Gray, D. Booth, Simon C. Potter, A. Goris, G. Band, A. Oturai, A. Strange, J. Saarela, C. Bellenguez, B. Fontaine, M. Gillman, B. Hemmer, R. Gwilliam, F. Zipp, Alagurevathi Jayakumar, Roland Martin, S. Leslie, S. Hawkins, E. Giannoulatou, S. D'alfonso, H. Blackburn, F. Martinelli Boneschi, J. Liddle, H. Harbo, M. L. Pérez, A. Spurkland, M. Waller, M. Mycko, M. Ricketts, M. Comabella, Naomi Hammond, I. Kockum, O. T. McCann, M. Ban, P. Whittaker, A. Kemppinen, P. Weston, C. Hawkins, S. Widaa, J. Zajicek, S. Dronov, N. Robertson, S. Bumpstead, L. Barcellos, R. Ravindrarajah, R. Abraham, L. Alfredsson, K. Ardlie, C. Aubin, A. Baker, K. Baker, S. Baranzini, L. Bergamaschi, R. Bergamaschi, A. Bernstein, A. Berthele, M. Boggild, J. Bradfield, D. Brassat, S. Broadley, D. Buck, H. Butzkueven, R. Capra, W. Carroll, P. Cavalla, E. Celius, S. Cepok, R. Chiavacci, F. Clerget-Darpoux, Katleen Clysters, G. Comi, M. Cossburn, I. Cournu-Rebeix, Mathew B. Cox, W. Cozen, B. Cree, A. Cross, D. Cusi, M. Daly, Emma Davis, P. D. de Bakker, M. Debouverie, M. D'hooghe, K. Dixon, R. Dobosi, B. Dubois, D. Ellinghaus, I. Elovaara, F. Esposito, Claire Fontenille, S. Foote, A. Franke, D. Galimberti, A. Ghezzi, J. Glessner, R. Gomez, O. Gout, C. Graham, S. Grant, F. Guerini, H. Hakonarson, P. Hall, A. Hamsten, H. Hartung, R. Heard, S. Heath, J. Hobart, M. Hoshi, C. Infante-Duarte, G. Ingram, Wendy M Ingram, T. Islam, M. Jagodic, M. Kabesch, A. Kermode, T. Kilpatrick, Cecilia Kim, N. Klopp, K. Koivisto, M. Larsson, M. Lathrop, J. Lechner-Scott, M. Leone, V. Leppä, U. Liljedahl, I. Bomfim, R. Lincoln, J. Link, Jianjun Liu, Å. Lorentzen, Sara Lupoli, F. Macciardi, T. Mack, M. Marriott, V. Martinelli, D. Mason, J. McCauley, F. Mentch, Inger‐Lise Mero, T. Mihalova, X. Montalban, J. Mottershead, K. Myhr, P. Naldi, W. Ollier, Alison Page, A. Palotie, J. Pelletier, L. Piccio, T. Pickersgill, F. Piehl, Susan Pobywajlo, H. Quach, P. Ramsay, M. Reunanen, R. Reynolds, J. Rioux, M. Rodegher, S. Roesner, J. Rubio, I. Rückert, M. Salvetti, E. Salvi, A. Santaniello, C. Schaefer, S. Schreiber, C. Schulze, R. Scott, F. Sellebjerg, K. Selmaj, D. Sexton, L. Shen, Brigid Simms-Acuna, S. Skidmore, P. Sleiman, C. Smestad, P. Sørensen, H. Søndergaard, J. Stankovich, R. Strange, A. Sulonen, E. Sundqvist, A. Syvänen, F. Taddeo, B. Taylor, J. Blackwell, P. Tienari, E. Bramon, A. Tourbah, M. Brown, E. Tronczyńska, J. Casas, N. Tubridy, A. Corvin, J. Vickery, Janusz Jankowski, P. Villoslada, H. Markus, Kai Wang, C. Mathew, J. Wason, C. Palmer, H. Wichmann, R. Plomin, E. Willoughby, A. Rautanen, J. Winkelmann, M. Wittig, R. Trembath, J. Yaouanq, A. Viswanathan, Haitao Zhang, N. Wood, R. Zuvich, P. Deloukas, C. Langford, A. Duncanson, J. Oksenberg, M. Pericak-Vance, J. Haines, T. Olsson, J. Hillert, A. Ivinson, P. D. De Jager, L. Peltonen, G. Stewart, D. Hafler, S. Hauser, G. McVean, P. Donnelly, Alastair Compston +241 moresemanticscholar +1 more sourceTargeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling
Advanced Science, EarlyView.Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling +9 morewiley +1 more sourceOfatumumab in pediatric multiple sclerosis: a case series. [PDF]
Ther Adv Neurol DisordWu W, Ran Y, Hou C, Zhu H, Wu W, Chen WX, Zheng K, Shen H, Deng H, Tang Y, Liao Y, Liang W, Mo X, Gao Y, Li X. +14 moreeuropepmc +1 more sourceParabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang +5 morewiley +1 more sourceMicroglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation
Advanced Science, EarlyView.A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu +8 morewiley +1 more sourceSex differences in multiple sclerosis relapse presentation and outcome: a retrospective, monocentric study of 134 relapse events [PDF]
Pauline Thränhardt, Admirim Veselaj, Christoph Friedli, Franca Wagner, Stefanie Marti, Lara Diem, Helly Hammer, Piotr Radojewski, Roland Wiest, Andrew Chan, Robert Hoepner, Anke Salmen +11 moreopenalex +1 more source
