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Seminars in Neurology, 2007
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that commonly leads to inflammatory and atrophic brain pathology, often causing cognitive impairment. MS-associated cognitive impairment was first described over a century ago.
Ralph Benedict1, Julie Bobholz2
semanticscholar +3 more sources
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that commonly leads to inflammatory and atrophic brain pathology, often causing cognitive impairment. MS-associated cognitive impairment was first described over a century ago.
Ralph Benedict1, Julie Bobholz2
semanticscholar +3 more sources
Science, 2022
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on ...
K. Bjørnevik +10 more
semanticscholar +1 more source
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on ...
K. Bjørnevik +10 more
semanticscholar +1 more source
Diagnosis and Treatment of Multiple Sclerosis: A Review.
Journal of the American Medical Association (JAMA), 2021Importance Multiple sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system characterized by inflammatory demyelination with axonal transection. MS affects an estimated 900 000 people in the US.
Marisa P. McGinley +2 more
semanticscholar +1 more source
Medicine, 2000
Multiple sclerosis is primarily an inflammatory disorder of the brain and spinal cord in which focal lymphocytic infiltration leads to damage of myelin and axons. Initially, inflammation is transient and remyelination occurs but is not durable. Hence, the early course of disease is characterised by episodes of neurological dysfunction that usually ...
Alastair, Compston, Alasdair, Coles
openaire +5 more sources
Multiple sclerosis is primarily an inflammatory disorder of the brain and spinal cord in which focal lymphocytic infiltration leads to damage of myelin and axons. Initially, inflammation is transient and remyelination occurs but is not durable. Hence, the early course of disease is characterised by episodes of neurological dysfunction that usually ...
Alastair, Compston, Alasdair, Coles
openaire +5 more sources
The Immune Response in Multiple Sclerosis.
Annual Review of Pathology, 2021Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of the CNS by immune cells ...
Sofía Rodríguez Murúa +2 more
semanticscholar +1 more source
IMMUNOLOGY OF MULTIPLE SCLEROSIS
Annual Review of Immunology, 2005▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing genetic trait and probably requires an inciting environmental insult such as a viral infection to trigger the disease. The activation of CD4+autoreactive T cells and their differentiation into a Th1 phenotype are a crucial events in the initial steps, and these ...
Sospedra, Mireia, Martin, Roland
openaire +5 more sources
2016
Due to its sensitivity to the different multiple sclerosis (MS)-related abnormalities, magnetic resonance imaging (MRI) has become an established tool to diagnose MS and to monitor its evolution. MRI has been included in the diagnostic workup of patients with clinically isolated syndromes suggestive of MS, and ad hoc criteria have been proposed and are
FILIPPI , MASSIMO, Preziosa P, Rocca MA
openaire +4 more sources
Due to its sensitivity to the different multiple sclerosis (MS)-related abnormalities, magnetic resonance imaging (MRI) has become an established tool to diagnose MS and to monitor its evolution. MRI has been included in the diagnostic workup of patients with clinically isolated syndromes suggestive of MS, and ad hoc criteria have been proposed and are
FILIPPI , MASSIMO, Preziosa P, Rocca MA
openaire +4 more sources
Identifying Progression In Multiple Sclerosis: New Perspectives.
Annals of Neurology, 2020The identification of progression in multiple sclerosis is typically retrospective. Given the profound burden of progressive multiple sclerosis, and the recent development of effective treatments for these patients, there is a need to establish measures ...
M. Filippi +9 more
semanticscholar +1 more source
Immunological Reviews, 2005
Summary: Multiple sclerosis (MS) is a complex genetic disease associated with inflammation in the central nervous system (CNS) white matter and is thought to be mediated by autoimmune processes. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS.
David A, Hafler +5 more
openaire +2 more sources
Summary: Multiple sclerosis (MS) is a complex genetic disease associated with inflammation in the central nervous system (CNS) white matter and is thought to be mediated by autoimmune processes. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS.
David A, Hafler +5 more
openaire +2 more sources
Nursing Standard, 1990
The Multiple Sclerosis Society of Great Britain and Northern Ireland has an impressive publication programme which includes booklets, sheets, periodicals, and audio and video cassettes. The Society provides general information for adults and children whose lives arc affected directly or indirectly by MS; lecture notes and resource packs for the health ...
Chris Eberhardie, Chris Eberhardie
openaire +2 more sources
The Multiple Sclerosis Society of Great Britain and Northern Ireland has an impressive publication programme which includes booklets, sheets, periodicals, and audio and video cassettes. The Society provides general information for adults and children whose lives arc affected directly or indirectly by MS; lecture notes and resource packs for the health ...
Chris Eberhardie, Chris Eberhardie
openaire +2 more sources